Essential Role of STAT3 in Body Weight and Glucose Homeostasis

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

STATs and Gene Regulation

1997 • 3,927 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Leptin Inhibits Bone Formation through a Hypothalamic Relay

2000 • 2,045 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2001 • 1,202 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

What does Stat3 do?

2002 • 810 citations

The Stat family in cytokine signaling

2001 • 723 citations

What does Stat3 do?

2002 • 685 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1999 • 521 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

2002 • 467 citations

Essential role of STAT3 for embryonic stem cell pluripotency

1999 • 404 citations

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

2002 • 370 citations

Functional Roles of STAT Family Proteins: Lessons from Knockout Mice

1999 • 344 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver

2001 • 331 citations

Transgenic mice with green fluorescent protein-labeled pancreatic β-cells

2003 • 299 citations

Precision and Accuracy of Dual‐Energy X‐ray Absorptiometry for Determining in Vivo Body Composition of Mice

2000 • 299 citations

Modulation of Circulating Leptin Levels by Its Soluble Receptor

2001 • 266 citations

The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of western diet feeding

2000 • 265 citations

Series Introduction: JAK-STAT signaling in human disease

2002 • 219 citations

Leptin: a multifunctional hormone

2000 • 211 citations

Targeted Expression of Placental Lactogen in the Beta Cells of Transgenic Mice Results in Beta Cell Proliferation, Islet Mass Augmentation, and Hypoglycemia

2000 • 209 citations

Series Introduction: JAK-STAT signaling in human disease

2002 • 186 citations

Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult

2002 • 184 citations

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

1998 • 177 citations

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1999 • 172 citations

Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons

2001 • 146 citations

Identification and function of neonatal Fc receptor in mammary gland of lactating mice

1999 • 115 citations

Stat3 in Thymic Epithelial Cells Is Essential for Postnatal Maintenance of Thymic Architecture and Thymocyte Survival

2001 • 109 citations

New mouse model to study islet transplantation in insulin-dependent diabetes mellitus

2002 • 90 citations

Leptin signalling in pancreatic islets and clonal insulin-secreting cells

1999 • 65 citations

STAT3 Deficiency in Keratinocytes Leads to Compromised Cell Migration through Hyperphosphorylation of p130

2002 • 58 citations

Down-Regulated STAT3 Messenger Ribonucleic Acid and STAT3 Protein in the Hypothalamic Arcuate Nucleus of the Obese Leptin-Deficient (ob/ob) Mouse**This research was supported by grants from the Swedish Medical Research Council (334X-10358) and the Swedish Society of Medical Research and by funds from the Karolinska Institutet.

2000 • 33 citations

Lose weight STAT: CNTF tops leptin

2001 • 29 citations

Multi-functional roles of Stat3 revealed by conditional gene targeting.

2001 • 21 citations

Interleukin‐1β activates a short STAT‐3 isoform in clonal insulin‐secreting cells

1999 • 18 citations

Tissue-specific expression of the rat insulin 1 gene in vivo requires both the enhancer and promoter regions

1995 • 17 citations