Epithelial Sodium Channel and the Control of Sodium Balance: Interaction Between Genetic and Environmental Factors

Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet

2001 • 5,241 citations

Molecular basis of human hypertension: Role of angiotensinogen

1992 • 1,861 citations

Molecular Mechanisms of Human Hypertension

2001 • 1,672 citations

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

1994 • 1,238 citations

Epithelial sodium channels: function, structure, and regulation

1997 • 1,154 citations

Epithelial Sodium Channel/Degenerin Family of Ion Channels: A Variety of Functions for a Shared Structure

2002 • 1,007 citations

Blood Pressure Control—Special Role of the Kidneys and Body Fluids

1991 • 942 citations

Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice

1996 • 873 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

1996 • 794 citations

Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome

1995 • 743 citations

Association of a human G-protein β3 subunit variant with hypertension

1998 • 732 citations

Epithelial sodium channel regulated by aldosterone-induced protein sgk

1999 • 728 citations

Molecular Genetics of Human Blood Pressure Variation

1996 • 637 citations

Effect of Reduced Dietary Sodium on Blood Pressure

1996 • 559 citations

An epithelial serine protease activates the amiloride-sensitive sodium channel

1997 • 509 citations

sgk Is an Aldosterone-induced Kinase in the Renal Collecting Duct

1999 • 452 citations

Human airway ion transport. Part one.

1994 • 446 citations

Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach

1996 • 418 citations

A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion

1963 • 417 citations

The effect of increased salt intake on blood pressure of chimpanzees

1995 • 416 citations

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

1995 • 408 citations

The heterotetrameric architecture of the epithelial sodium channel (ENaC)

1998 • 408 citations

Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I

1998 • 403 citations

Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK

2001 • 377 citations

Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry.

1994 • 376 citations

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

1999 • 358 citations

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.

1995 • 357 citations

Pulmonary Epithelial Sodium-Channel Dysfunction and Excess Airway Liquid in Pseudohypoaldosteronism

1999 • 345 citations

SODIUM CHANNELS IN ALVEOLAR EPITHELIAL CELLS: Molecular Characterization, Biophysical Properties, and Physiological Significance

1999 • 343 citations

Liddle's Syndrome Revisited -- A Disorder of Sodium Reabsorption in the Distal Tubule

1994 • 342 citations

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.

1995 • 304 citations

Molecular Cloning and Functional Expression of a Novel Amiloride-sensitive Na+ Channel

1995 • 298 citations

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na⁺channel

2001 • 290 citations

Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.

1998 • 247 citations

Association of hypertension with T594M mutation in β subunit of epithelial sodium channels in black people resident in London

1998 • 245 citations

Disruption of the β subunit of the epithelial Na ⁺ channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype

1999 • 243 citations

A novel spice–site mutation in the γ subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families

1996 • 241 citations

Electrophysiological and Biochemical Evidence That DEG/ENaC Cation Channels Are Composed of Nine Subunits

1998 • 234 citations

MOLECULAR MODELING OF MECHANOTRANSDUCTION IN THE NEMATODE CAENORHABDITIS ELEGANS

1997 • 230 citations

Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene.

1996 • 226 citations

Differential subcellular localization of ENaC subunits in mouse kidney in response to high- and low-Na diets

2000 • 225 citations

Subunit Stoichiometry of the Epithelial Sodium Channel

1998 • 222 citations

Transcriptome of a mouse kidney cortical collecting duct cell line: Effects of aldosterone and vasopressin

2001 • 215 citations

Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination

2000 • 211 citations

A mutation causing pseudohypoaldosteronism type1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel

1997 • 208 citations

A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess.

1995 • 200 citations

Lung epithelial Na channel subunits are differentially regulated during development and by steroids

1995 • 199 citations

Epithelial Na+ channel subunits in rat taste cells: Localization and regulation by aldosterone

1999 • 189 citations

Type I Pseudohypoaldosteronism Includes Two Clinically and Genetically Distinct Entities with either Renal or Multiple Target Organ Defects

1991 • 186 citations

A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes.

1995 • 181 citations

Immunocytochemical and immunoelectron microscopic localization of α-, β-, and γ-ENaC in rat kidney

2001 • 172 citations

Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels

1999 • 168 citations

A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism

1997 • 167 citations

Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome

1997 • 164 citations

DEG/ENaC channels: A touchy superfamily that watches its salt

1999 • 158 citations

Urinary Electrolyte Excretion in 24 Hours and Blood Pressure in the INTERSALT Study

1994 • 155 citations

Heterogeneous responses to changes in dietary salt intake: the salt-sensitivity paradigm

1997 • 146 citations

Molecular Basis of Human Salt Sensitivity: The Role of the 11β-Hydroxysteroid Dehydrogenase Type 2*

1999 • 143 citations

Seven Lessons From Two Candidate Genes in Human Essential Hypertension

1999 • 142 citations

A Mouse Model for Liddle's Syndrome

1999 • 140 citations

Renal physiology of the mouse

2000 • 139 citations

α-Adducin polymorphisms and renal sodium handling in essential hypertensive patients

1998 • 138 citations

Association of the G _s α Gene With Essential Hypertension and Response to β-Blockade

1999 • 137 citations

Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the β-subunit of the amiloride-sensitive epithelial sodium channel

1999 • 135 citations

Cystic Fibrosis and the Salt Controversy

1999 • 135 citations

Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia

1997 • 133 citations

Number of Subunits Comprising the Epithelial Sodium Channel

1999 • 132 citations

Effect of reduced dietary sodium on blood pressure: a meta-analysis of randomized controlled trials

1996 • 125 citations

Genetic Variants in the Epithelial Sodium Channel in Relation to Aldosterone and Potassium Excretion and Risk for Hypertension

1999 • 121 citations

Animal models of human genetic diseases

1993 • 117 citations

Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of its α subunit

1999 • 116 citations

Urinary Electrolyte Excretion in 24 Hours and Blood Pressure in the INTERSALT Study

1994 • 113 citations

A New Locus on Chromosome 12p13.3 for Pseudohypoaldosteronism Type II, an Autosomal Dominant Form of Hypertension

2000 • 112 citations

Mutational Analysis of Cysteine-rich Domains of the Epithelium Sodium Channel (ENaC)

1999 • 109 citations

1996 Homer Smith Award Lecture. Cum grano salis

1997 • 109 citations

Noncoordinated expression of alpha-, beta-, and gamma-subunit mRNAs of epithelial Na+ channel along rat respiratory tract

1997 • 107 citations

The Phe-Met-Arg-Phe-amide-activated Sodium Channel Is a Tetramer

1998 • 103 citations

Molecular Basis for Hypertension in the “Type II Variant” of Apparent Mineralocorticoid Excess

1998 • 101 citations

Lung symptoms in pseudohypoaldosteronism type 1 are associated with deficiency of the α-subunit of the epithelial sodium channel

1999 • 98 citations

High-Altitude Pulmonary Edema: From Exaggerated Pulmonary Hypertension to a Defect in Transepithelial Sodium Transport

1999 • 94 citations

Genotype–phenotype analysis of a newly discovered family with Liddleʼs syndrome

1997 • 94 citations

Dysfunction of epithelial sodium transport: From human to mouse

2000 • 93 citations

Preliminary Evidence of Linkage of Salt Sensitivity in Black Americans at the β ₂ -Adrenergic Receptor Locus

1997 • 91 citations

Epithelial sodium channel in human epidermal keratinocytes: expression of its subunits and relation to sodium transport and differentiation

1999 • 87 citations

Sodium transport-related proteins in the mammalian distal nephron - distribution, ontogeny and functional aspects

1999 • 87 citations

A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess

1995 • 78 citations

Distribution of ion transport mRNAs throughout murine nose and lung

2000 • 77 citations

A Family with Liddle’s Syndrome Caused by a New Missense Mutation in the β Subunit of the Epithelial Sodium Channel

1998 • 76 citations

Localisation of Pseudohypoaldosteronism Genes to Chromosome 16p12.2–13.11 and 12p13.1-Pter by Homozygosity Mapping

1996 • 76 citations

Quantitation and Localization of ENaC Subunit Expression in Fetal, Newborn, and Adult Mouse Lung

1999 • 72 citations

Pseudohypoaldosteronism in Eight Families: Different Forms of Inheritance Are Evidence for Various Genetic Defects

1990 • 64 citations

Angiotensinogen in Essential Hypertension

2001 • 63 citations

Two sporadic cases of liddle’s syndrome caused by de novo ENaC mutations

2001 • 62 citations

The ENaC Channel is Required for Normal Epidermal Differentiation

2002 • 62 citations

Location and function of the epithelial Na channel in the cochlea

2001 • 58 citations

Quantitative Trait Loci for Blood Pressure Exist Near the IGF-1, the Liddle Syndrome, the Angiotensin II-Receptor Gene and the Renin Loci in Man

1999 • 55 citations

Molecular Basis of Human Salt Sensitivity: The Role of the 11 -Hydroxysteroid Dehydrogenase Type 2

1999 • 55 citations

Developmental and cellular expression pattern of epithelial sodium channel α, β and γ subunits in the inner ear of the rat

2001 • 51 citations

Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension

1999 • 43 citations

G proteins and hypertension: An alternative candidate gene approach

1998 • 35 citations

Mechano-electrical transduction in mice lacking the α-subunit of the epithelial sodium channel

1999 • 35 citations

Disorders of the epithelial sodium channel: Insights into the regulation of extracellular volume and blood pressure

1999 • 34 citations

Compound Heterozygous Mutations in the γ Subunit Gene of ENaC (1627delG and 1570-1G→A) in One Sporadic Japanese Patient with a Systemic Form of Pseudohypoaldosteronism Type 1

2001 • 34 citations

Epithelial sodium channel regulatory proteins identified by functional expression cloning

1998 • 32 citations

Epithelial Sodium Channels are Upregulated During Epidermal Differentiation

1999 • 32 citations

Glucagon Receptor Gene Mutation (Gly40Ser) in Human Essential Hypertension

1999 • 32 citations

Disorders of the Epithelial Na<sup>+</sup> Channel in Liddle’s Syndrome and Autosomal Recessive Pseudohypoaldosteronism Type 1

2000 • 31 citations

The Amiloride-Sensitive Na+ Channel: From Primary Structure to Function

1997 • 30 citations

Genetic, Biochemical, and Clinical Studies of Patients With A328V or R213C Mutations in 11βHSD2 Causing Apparent Mineralocorticoid Excess

1999 • 30 citations

Lung Development

1986 • 28 citations

A Family with Liddle's Syndrome Caused by a New Missense Mutation in the Subunit of the Epithelial Sodium Channel

1998 • 26 citations

Mechanism of action of amiloride: a molecular prospective.

1999 • 26 citations

Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism

1999 • 24 citations

Role of the Epithelial Sodium Channel in Lung Liquid Clearance

1997 • 23 citations

Two sporadic cases of liddle's syndrome caused by de novo ENaC mutations

2001 • 19 citations

Compound Heterozygous Mutations in the Subunit Gene of ENaC (1627delG and 1570-1G A) in One Sporadic Japanese Patient with a Systemic Form of Pseudohypoaldosteronism Type 1

2001 • 13 citations

Aldosterone-related genetic effects in hypertension

2000 • 10 citations

Gordonʼs syndrome

2000 • 3 citations

Chapter 5 Regulation of ENaC by Interacting Proteins and by Ubiquitination

1999 • 1 citations