Disorders of the epithelial sodium channel: Insights into the regulation of extracellular volume and blood pressure

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

1994 • 1,943 citations

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

1994 • 1,238 citations

Epithelial sodium channel related to proteins involved in neurodegeneration

1993 • 911 citations

Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice

1996 • 873 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

1996 • 794 citations

Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome

1995 • 743 citations

Epithelial sodium channel regulated by aldosterone-induced protein sgk

1999 • 728 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

1999 • 663 citations

An epithelial serine protease activates the amiloride-sensitive sodium channel

1997 • 509 citations

Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling

1994 • 483 citations

Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach

1996 • 418 citations

A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion

1963 • 417 citations

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

1995 • 408 citations

The heterotetrameric architecture of the epithelial sodium channel (ENaC)

1998 • 408 citations

Mineralocorticoid receptor knockout mice: Pathophysiology of Na ⁺ metabolism

1998 • 404 citations

Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I

1998 • 403 citations

Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans

1994 • 390 citations

Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel

1995 • 390 citations

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

1999 • 358 citations

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.

1995 • 357 citations

Liddle's Syndrome Revisited -- A Disorder of Sodium Reabsorption in the Distal Tubule

1994 • 342 citations

Expression cloning of an epithelial amiloride‐sensitive Na⁺ channel

1993 • 340 citations

Dahl salt-susceptible and salt-resistant rats. A review.

1982 • 328 citations

The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans

1996 • 317 citations

Membrane topology of the epithelial sodium channel in intact cells

1994 • 311 citations

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.

1995 • 304 citations

Molecular Cloning and Functional Expression of a Novel Amiloride-sensitive Na+ Channel

1995 • 298 citations

Structure and function of the WW domain

1996 • 290 citations

Two point mutations within the adducin genes are involved in blood pressure variation.

1994 • 281 citations

The Activity of the Epithelial Sodium Channel Is Regulated by Clathrin-mediated Endocytosis

1997 • 276 citations

Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons

1998 • 258 citations

Identification of Amino Acid Residues in the α, β, and γ Subunits of the Epithelial Sodium Channel (ENaC) Involved in Amiloride Block and Ion Permeation

1997 • 254 citations

Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.

1998 • 247 citations

Association of hypertension with T594M mutation in β subunit of epithelial sodium channels in black people resident in London

1998 • 245 citations

Disruption of the β subunit of the epithelial Na ⁺ channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype

1999 • 243 citations

A novel spice–site mutation in the γ subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families

1996 • 241 citations

Electrophysiological and Biochemical Evidence That DEG/ENaC Cation Channels Are Composed of Nine Subunits

1998 • 234 citations

Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel

1995 • 234 citations

Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene.

1996 • 226 citations

Membrane topology of the amiloride-sensitive epithelial sodium channel.

1994 • 220 citations

Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel.

1994 • 219 citations

A Molecular Component of the Arterial Baroreceptor Mechanotransducer

1998 • 218 citations

Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21

1997 • 213 citations

Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate.

1986 • 211 citations

A mutation causing pseudohypoaldosteronism type1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel

1997 • 208 citations

Lung epithelial Na channel subunits are differentially regulated during development and by steroids

1995 • 199 citations

Diversity of Channels Generated by Different Combinations of Epithelial Sodium Channel Subunits

1997 • 179 citations

Inhibition of the Epithelial Na+ Channel by Interaction of Nedd4 with a PY Motif Deleted in Liddle's Syndrome

1998 • 178 citations

Expression of the epithelial Na+ channel in the developing rat lung

1993 • 177 citations

In vivo phosphorylation of the epithelial sodium channel

1998 • 168 citations

A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism

1997 • 167 citations

Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.

1998 • 161 citations

Regulation of rENaC mRNA by dietary NaCl and steroids: organ, tissue, and steroid heterogeneity

1998 • 158 citations

Transcriptional control of sodium transport in tight epithelia by adrenal steroids

1995 • 151 citations

Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat

1993 • 149 citations

Glucocorticoid Induction of Epithelial Sodium Channel Expression in Lung and Renal Epithelia Occurs via trans-Activation of a Hormone Response Element in the 5′-Flanking Region of the Human Epithelial Sodium Channel α Subunit Gene

1999 • 142 citations

Nedd4 mediates control of an epithelial Na ⁺ channel in salivary duct cells by cytosolic Na ⁺

1998 • 140 citations

Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the β-subunit of the amiloride-sensitive epithelial sodium channel

1999 • 135 citations

Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia

1997 • 133 citations

Genetic Analysis of the β Subunit of the Epithelial Na ⁺ Channel in Essential Hypertension

1998 • 124 citations

Methylation Increases Sodium Transport into A6 Apical Membrane Vesicles: Possible Mode of Aldosterone Action

1984 • 121 citations

Mutational Analysis of Cysteine-rich Domains of the Epithelium Sodium Channel (ENaC)

1999 • 109 citations

Mechanosensation and the DEG/ENaC Ion Channels

1996 • 105 citations

A novel variant of the beta-subunit of the amiloride-sensitive sodium channel in African Americans.

1996 • 103 citations

Genotype–phenotype analysis of a newly discovered family with Liddleʼs syndrome

1997 • 94 citations

Cytosolic Na+ controls and epithelial Na+ channel via the Go guanine nucleotide-binding regulatory protein.

1996 • 87 citations

Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC)

1997 • 85 citations

Mutations and Variants of the Epithelial Sodium Channel Gene in Liddle’s Syndrome and Primary Hypertension

1998 • 81 citations

rENaC is the predominant Na+ channel in the apical membrane of the rat renal inner medullary collecting duct.

1995 • 77 citations

A Family with Liddle’s Syndrome Caused by a New Missense Mutation in the β Subunit of the Epithelial Sodium Channel

1998 • 76 citations

Liddle’s Syndrome: Prospective Genetic Screening and Suppressed Aldosterone Secretion in an Extended Kindred*

1997 • 70 citations

Enhancement of electrogenic Na+ transport across rat inner medullary collecting duct by glucocorticoid and by mineralocorticoid hormones.

1990 • 65 citations

Differences in synergistic actions of vasopressin and deoxycorticosterone in rat and rabbit CCD

1990 • 64 citations

Expression and localization of amiloride-sensitivesodium channel indicate a role for non-taste cells in tasteperception.

1994 • 63 citations

Genetic analysis of the epithelial sodium channel in Liddleʼs syndrome

1998 • 59 citations

Carboxylmethylation of the β Subunit of xENaC Regulates Channel Activity

1998 • 58 citations

Role of the α-, β-, and γ-Subunits of Epithelial Sodium Channel in a Model of Polygenic Hypertension

1997 • 53 citations

Loss of protein kinase C inhibition in the β-T594M variant of the amiloride-sensitive Na ⁺ channel

1997 • 51 citations

Regulation of sodium transport in M-1 cells

1998 • 48 citations

Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C

1996 • 45 citations

Assembly of the Epithelial Na+ Channel Evaluated Using Sucrose Gradient Sedimentation Analysis

1998 • 44 citations

Identification of a single cytosine base insertion mutation at Arg-597 of the beta subunit of the human epithelial sodium channel in a family with Liddle's disease

1998 • 43 citations

Subunit Stoichiometry of a Core Conduction Element in a Cloned Epithelial Amiloride-Sensitive Na+ Channel

1998 • 43 citations

Developmental regulation of epithelial sodium channel subunit mRNA expression in rat colon and lung

1998 • 41 citations

Regulation of a Sodium Channel-associated G-protein by Aldosterone

1996 • 39 citations

Developmental expression of the epithelial Na⁺channel in kidney and uroepithelia

1999 • 37 citations

Ion transport by the collecting duct.

1993 • 37 citations

Aldosterone-induced and GTP-stimulated methylation of a 90-kDa polypeptide in the apical membrane of A6 epithelia.

1993 • 36 citations

Amiloride-sensitive Na⁺channels in pelvic uroepithelium involved in renal sensory receptor activation

1998 • 36 citations

The diagnosis of Liddle syndrome by identification of a mutation in the beta subunit of the epithelial sodium channel.

1998 • 34 citations

Cytosolic Na^+ controls an epithelial Na^+ chanel via the G_o guaninine nucleotide-binding regulatory protein

1996 • 34 citations

Induction of resistance to mineralocorticoid hormone in cultured inner medullary collecting duct cells by TGF-beta 1

1994 • 32 citations

Polymorphisms in the carboxy-terminus of the epithelial sodium channel in rat models for hypertension

1997 • 31 citations

Peptide block of constitutively activated Na+ channels in Liddle's disease

1996 • 29 citations

Differential regulation of CHIF mRNA by potassium intake and aldosterone

1997 • 28 citations

IMCD cells cultured from Dahl S rats absorb more Na+ than Dahl R rats

1996 • 26 citations

The Basis of Higher Na + Transport by Inner Medullary Collecting Duct Cells from Dahl Salt-Sensitive Rats: Implicating the Apical Membrane Na + Channel

1997 • 25 citations

Membrane Receptors for Aldosterone: A New Concept of Nongenomic Mineralocorticoid Action

1993 • 14 citations

Regulation of Epithelial Na + Permeability by Protein Kinase C is Tissue Specific

1996 • 12 citations