A novel mouse Nedd4 protein suppresses the activity of the epithelial Na⁺channel

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

SMART, a simple modular architecture research tool: Identification of signaling domains

1998 • 3,523 citations

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

1994 • 1,943 citations

Initiation of translation in prokaryotes and eukaryotes

1999 • 1,379 citations

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

1994 • 1,238 citations

Epithelial sodium channels: function, structure, and regulation

1997 • 1,154 citations

Epithelial sodium channel related to proteins involved in neurodegeneration

1993 • 911 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

1996 • 794 citations

Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome

1995 • 743 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS

1998 • 617 citations

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

1995 • 556 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels

1999 • 461 citations

Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach

1996 • 418 citations

A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion

1963 • 417 citations

The heterotetrameric architecture of the epithelial sodium channel (ENaC)

1998 • 408 citations

Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.

1996 • 397 citations

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

1999 • 358 citations

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.

1995 • 357 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction

1989 • 321 citations

Membrane topology of the epithelial sodium channel in intact cells

1994 • 311 citations

Corticosteroid-Dependent Sodium Transport in a Novel Immortalized Mouse Collecting Duct Principal Cell Line

1999 • 292 citations

A novel spice–site mutation in the γ subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families

1996 • 241 citations

Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene.

1996 • 226 citations

Membrane topology of the amiloride-sensitive epithelial sodium channel.

1994 • 220 citations

Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel.

1994 • 219 citations

The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization

1997 • 199 citations

Inhibition of the Epithelial Na+ Channel by Interaction of Nedd4 with a PY Motif Deleted in Liddle's Syndrome

1998 • 178 citations

cDNA Cloning, Expression Analysis, and Mapping of the MouseNedd4Gene

1997 • 142 citations

Nedd4 mediates control of an epithelial Na ⁺ channel in salivary duct cells by cytosolic Na ⁺

1998 • 140 citations

Electrophysiological Characterization of the Rat Epithelial Na+ Channel (rENaC) Expressed in MDCK Cells

1998 • 126 citations

All Three WW Domains of Murine Nedd4 Are Involved in the Regulation of Epithelial Sodium Channels by Intracellular Na+

1999 • 123 citations

Liddle syndrome: An autosomal dominant form of human hypertension

1998 • 100 citations

Characterization of the Structure and Function of W → F WW Domain Variants: Identification of a Natively Unfolded Protein That Folds upon Ligand Binding

1999 • 81 citations

A Family with Liddle’s Syndrome Caused by a New Missense Mutation in the β Subunit of the Epithelial Sodium Channel

1998 • 76 citations

Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits

2000 • 54 citations

Identification of a single cytosine base insertion mutation at Arg-597 of the beta subunit of the human epithelial sodium channel in a family with Liddle's disease

1998 • 43 citations

NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel

1998 • 35 citations

Novel isoforms of the β and γ subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing

1997 • 35 citations

NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel

1998 • 28 citations

A Family with Liddle's Syndrome Caused by a New Missense Mutation in the Subunit of the Epithelial Sodium Channel

1998 • 26 citations

Information transfer between large and small two-dimensional polyacrylamide gel electrophoresis

1999 • 9 citations

Molecular Cloning of Nedd4 fromXenopus Laevis

1998 • 9 citations