Role of Chemokines and Chemokine Receptors in Shaping the Effector Phase of the Antitumor Immune Response

Inflammation and cancer

2002 • 14,174 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

2008 • 1,560 citations

Lymphocyte traffic control by chemokines

2001 • 1,225 citations

The Chemokine Superfamily Revisited

2012 • 1,074 citations

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

1998 • 1,001 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

2012 • 855 citations

Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction

2006 • 795 citations

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

2009 • 667 citations

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

2011 • 618 citations

In Breast Carcinoma Tissue, Immature Dendritic Cells Reside within the Tumor, Whereas Mature Dendritic Cells Are Located in Peritumoral Areas

1999 • 540 citations

Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

2000 • 526 citations

Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity

2004 • 430 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

Chemokines: agents for the immunotherapy of cancer?

2002 • 402 citations

The chemokine system and cancer

2011 • 384 citations

In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor

2007 • 362 citations

Chemokines in cancer

2002 • 344 citations

Rapid leukocyte integrin activation by chemokines

2002 • 341 citations

T cell costimulation by chemokine receptors

2005 • 336 citations

Principles of adoptive T cell cancer therapy

2007 • 260 citations

Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer.

2001 • 247 citations

Random migration precedes stable target cell interactions of tumor-infiltrating T cells

2006 • 220 citations

Combined chemokine and cytokine gene transfer enhances antitumor immunity

1996 • 215 citations

Macrophage inflammatory protein 3α transgene attracts dendritic cells to established murine tumors and suppresses tumor growth

2000 • 174 citations

CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3–kinase– independent manner

2007 • 166 citations

Surface-bound chemokines capture and prime T cells for synapse formation

2006 • 163 citations

RANTES and MIP-1α Activate Stats in T Cells

1998 • 155 citations

Stop and Go Traffic to Tune T Cell Responses

2004 • 143 citations

RANTES Secretion by Gene-Modified Tumor Cells Results in Loss of TumorigenicityIn Vivo:Role of Immune Cell Subpopulations

1996 • 142 citations

Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment

2010 • 139 citations

CXC Chemokine Receptor 3 Expression by Activated CD8+ T cells Is Associated with Survival in Melanoma Patients with Stage III Disease

2004 • 134 citations

Myeloid-Derived Suppressor Cells

2007 • 133 citations

The high expression of Fractalkine results in a better prognosis for colorectal cancer patients

2005 • 127 citations

Local and systemic effects of an allogeneic tumor cell vaccine combining transgenic human lymphotactin with interleukin-2 in patients with advanced or refractory neuroblastoma

2003 • 120 citations

Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses

2007 • 119 citations

RANTES expression is a predictor of survival in stage I lung adenocarcinoma.

2002 • 110 citations

Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models

1999 • 105 citations

The pros and cons of chemokines in tumor immunology

2012 • 104 citations

CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate Antigen

2005 • 94 citations

HIGH EXPRESSION OF CHEMOKINE GENE AS A FAVORABLE PROGNOSTIC FACTOR IN RENAL CELL CARCINOMA

2004 • 86 citations

Chemokine-Guided CD4+ T Cell Help Enhances Generation of IL-6RαhighIL-7Rαhigh Prememory CD8+ T Cells

2007 • 86 citations

Intratumoral Induction of CD103 Triggers Tumor-Specific CTL Function and CCR5-Dependent T-Cell Retention

2009 • 83 citations

A potential immune escape mechanism by melanoma cells through the activation of chemokine-induced T cell death

2001 • 69 citations

Chemokines, Costimulatory Molecules and Fusion Proteins for the Immunotherapy of Solid Tumors

2011 • 57 citations

CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy

2012 • 48 citations

Strong cytotoxic T lymphocyte responses to a macrophage inflammatory protein 1alpha-expressing tumor: linkage between inflammation and specific immunity.

1999 • 41 citations

Host Absence of CCR5 Potentiates Dendritic Cell Vaccination

2003 • 40 citations

Clinical utilization of chemokines to combat cancer: the double-edged sword

2007 • 39 citations

Tumour-immune cell interactions modulated by chemokines

2008 • 37 citations

Lymphotactin cotransfection enhances the therapeutic efficacy of dendritic cells genetically modified with melanoma antigen gp100

2002 • 27 citations

Collagen 17A1 Gene Correction Using Spliceosome Mediated RNA Trans-splicing (SMaRT™) Technology.

2000 • 14 citations

CC chemokine receptor 6 (CCR6) is a marker for memory T cells that arrest on activated human dermal microvascular endothelium under shear stress.

2000 • 10 citations