Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment

The Inflammasomes

2010 • 4,840 citations

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

2010 • 3,500 citations

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

2009 • 2,348 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Batf3 Deficiency Reveals a Critical Role for CD8α ⁺ Dendritic Cells in Cytotoxic T Cell Immunity

2008 • 1,781 citations

IFI16 is an innate immune sensor for intracellular DNA

2010 • 1,498 citations

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

2009 • 1,000 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

2004 • 748 citations

Adoptive cell therapy for the treatment of patients with metastatic melanoma

2009 • 568 citations

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

2010 • 499 citations

Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy

2001 • 425 citations

Immune resistance orchestrated by the tumor microenvironment

2006 • 422 citations

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

2009 • 380 citations

Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes

2004 • 368 citations

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

2009 • 350 citations

Clinical Use of Anti‐CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

2009 • 281 citations

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy

2006 • 281 citations

B7-H1 pathway and its role in the evasion of tumor immunity

2003 • 272 citations

IDO and tolerance to tumors

2003 • 262 citations

T cell clonal anergy

1997 • 257 citations

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

2006 • 250 citations

Gene Signature in Melanoma Associated With Clinical Activity

2010 • 247 citations

The WNT/Beta-catenin pathway in melanoma

2006 • 236 citations

Failure at the Effector Phase: Immune Barriers at the Level of the Melanoma Tumor Microenvironment

2007 • 232 citations

Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma.

2003 • 175 citations

c-Met Is a Potentially New Therapeutic Target for Treatment of Human Melanoma

2007 • 155 citations

Transient T cell depletion causes regression of melanoma metastases

2008 • 153 citations

New Generation Vaccine Induces Effective Melanoma-Specific CD8+ T Cells in the Circulation but Not in the Tumor Site

2006 • 151 citations

Tumor progression despite massive influx of activated CD8+ T cells in a patient with malignant melanoma ascites

2006 • 143 citations

Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects

2005 • 132 citations

Imatinib Targeting of KIT-Mutant Oncoprotein in Melanoma

2008 • 131 citations

Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma

2005 • 101 citations

Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma

2008 • 90 citations

Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity

2005 • 90 citations

Homeostatic Proliferation as an Isolated Variable Reverses CD8+ T Cell Anergy and Promotes Tumor Rejection

2006 • 86 citations

Safety and antitumor activity of biweekly MDX-1106 (Anti-PD-1, BMS-936558/ONO-4538) in patients with advanced refractory malignancies.

2010 • 86 citations

Targeting the Primary Tumor to Generate CTL for the Effective Eradication of Spontaneous Metastases

2007 • 73 citations

Expression of defined genes identified by pretreatment tumor profiling: Association with clinical responses to the GSK MAGE- A3 immunotherapeutic in metastatic melanoma patients (EORTC 16032–18031)

2008 • 62 citations

Activated Stat-3 in Melanoma

2008 • 61 citations

Differentiation of CD8+ T Cells from Tumor-Invaded and Tumor-Free Lymph Nodes of Melanoma Patients: Role of Common γ-Chain Cytokines

2003 • 46 citations

Association of gene expression profile in metastatic melanoma and survival to a dendritic cell-based vaccine

2009 • 31 citations

Modulation of Inflammasome Activity for the Treatment of Auto-inflammatory Disorders

2010 • 24 citations

Chemokines expressed in melanoma metastases associated with T cell infiltration

2007 • 14 citations