Tumour-immune cell interactions modulated by chemokines

Inflammation and cancer

2002 • 14,174 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

The Biology of Chemokines and their Receptors

2000 • 2,416 citations

Cancer and the chemokine network

2004 • 2,292 citations

Taking dendritic cells into medicine

2007 • 2,044 citations

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

2002 • 1,941 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

1998 • 1,175 citations

The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes

2005 • 1,023 citations

IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking

2002 • 1,022 citations

Regulation of T Cell Immunity by Dendritic Cells

2001 • 984 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Role of tumor-associated macrophages in tumor progression and invasion

2006 • 838 citations

Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis

2005 • 758 citations

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1

2000 • 720 citations

Chemokines as regulators of T cell differentiation

2001 • 710 citations

Carcinogenesis of Helicobacter pylori

2007 • 672 citations

Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

2001 • 644 citations

Dancing to the tune of chemokines

2001 • 624 citations

RANTES: a versatile and controversial chemokine

2001 • 603 citations

The chemokine and chemokine receptor superfamilies and their molecular evolution.

2006 • 587 citations

Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas.

2001 • 496 citations

Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

Expression of CXCR4 and CXCL12 (SDF‐1) in human prostate cancers (PCa) in vivo

2003 • 440 citations

Differential CC chemokine-induced enhancement of T helper cell cytokine production.

1997 • 417 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

Chemokines and cancer

2006 • 413 citations

A novel dendritic cell subset involved in tumor immunosurveillance

2006 • 407 citations

Cancer CXC chemokine networks and tumour angiogenesis

2006 • 405 citations

Silencing of CXCR4 Blocks Breast Cancer Metastasis

2005 • 397 citations

Chemokines in cancer

2002 • 344 citations

Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome.

2003 • 342 citations

Targeting CCL2 with Systemic Delivery of Neutralizing Antibodies Induces Prostate Cancer Tumor RegressionIn vivo

2007 • 315 citations

The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses

2006 • 310 citations

The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3

2001 • 307 citations

From Malaria to Chemokine Receptor: The Emerging Physiologic Role of the Duffy Blood Group Antigen

1997 • 296 citations

Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma.

1999 • 294 citations

Active movement of T cells away from a chemokine

2000 • 293 citations

Dendritic Cell Subsets Differentially Regulate Angiogenesis in Human Ovarian Cancer

2004 • 283 citations

Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium

2007 • 277 citations

Chemokine CXCL10 Promotes Atherogenesis by Modulating the Local Balance of Effector and Regulatory T Cells

2006 • 277 citations

Chemoattractant Receptor Cross-desensitization

1999 • 275 citations

Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes

2004 • 266 citations

Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys

2000 • 259 citations

The Inducible CXCR3 Ligands Control Plasmacytoid Dendritic Cell Responsiveness to the Constitutive Chemokine Stromal Cell–derived Factor 1 (SDF-1)/CXCL12

2003 • 255 citations

Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient

2004 • 252 citations

Interaction of chemokines and glycosaminoglycans: A new twist in the regulation of chemokine function with opportunities for therapeutic intervention

2005 • 248 citations

Phase 2 Study of the Safety and Efficacy of Vicriviroc, a CCR5 Inhibitor, in HIV‐1–Infected, Treatment‐Experienced Patients: AIDS Clinical Trials Group 5211

2007 • 240 citations

BRAK/CXCL14 Is a Potent Inhibitor of Angiogenesis and a Chemotactic Factor for Immature Dendritic Cells

2004 • 239 citations

CCR4 as a novel molecular target for immunotherapy of cancer

2006 • 235 citations

Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia

2007 • 231 citations

Expression of Functional Chemokine Receptors CXCR3 and CXCR4 on Human Melanoma Cells

2001 • 230 citations

Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes

2007 • 230 citations

Cloning and Characterization of a Novel Promiscuous Human β-Chemokine Receptor D6

1997 • 229 citations

Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors

2007 • 214 citations

The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity.

2003 • 205 citations

Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-α

2002 • 200 citations

Regulation of Carcinogenesis by IL-5 and CCL11: A Potential Role for Eosinophils in Tumor Immune Surveillance

2007 • 199 citations

Loss of New Chemokine CXCL14 in Tumor Tissue Is Associated with Low Infiltration by Dendritic Cells (DC), while Restoration of Human CXCL14 Expression in Tumor Cells Causes Attraction of DC Both In Vitro and In Vivo

2005 • 197 citations

G Protein-Coupled Chemokine Receptors Induce Both Survival and Apoptotic Signaling Pathways

2002 • 189 citations

CXCL10 Promotes Invasion-Related Properties in Human Colorectal Carcinoma Cells

2007 • 183 citations

Study of tumor infiltrating lymphocytes and transforming growth factor-β as prognostic factors in breast carcinoma

1997 • 182 citations

High-Level Expression of Chemokine CXCL16 by Tumor Cells Correlates with a Good Prognosis and Increased Tumor-Infiltrating Lymphocytes in Colorectal Cancer

2007 • 180 citations

CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo

2004 • 170 citations

Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?

2006 • 168 citations

Chemokines in tumor angiogenesis and metastasis

2007 • 168 citations

Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture.

1998 • 163 citations

CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases

2006 • 162 citations

The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.

2002 • 157 citations

Antitumor Effects of the Mouse Chemokine 6Ckine/SLC Through Angiostatic and Immunological Mechanisms

2000 • 156 citations

Natural Killer Cells Produce T Cell–Recruiting Chemokines in Response to Antibody-Coated Tumor Cells

2006 • 148 citations

Detection and localization of MIP‐3α/LARC/exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer

1999 • 143 citations

RANTES Secretion by Gene-Modified Tumor Cells Results in Loss of TumorigenicityIn Vivo:Role of Immune Cell Subpopulations

1996 • 142 citations

Intratumoral Administration of Dendritic Cells Overexpressing CCL21 Generates Systemic Antitumor Responses and Confers Tumor Immunity

2004 • 141 citations

The chemokine CXCL14 (BRAK) stimulates activated NK cell migration: Implications for the downregulation of CXCL14 in malignancy

2006 • 134 citations

CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment

2007 • 134 citations

The CXC Chemokine, Monokine Induced by Interferon-gamma, Inhibits Non-Small Cell Lung Carcinoma Tumor Growth and Metastasis

2000 • 134 citations

The CXCL12–CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies

2004 • 130 citations

The CC Chemokine CKβ-11/MIP-3β/ELC/Exodus 3 Mediates Tumor Rejection of Murine Breast Cancer Cells Through NK Cells

2000 • 124 citations

Clinical stage-depending decrease of NK cell activity in multiple myeloma patients

2007 • 123 citations

Detection and localization of MIP-3?/LARC/exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer

1999 • 122 citations

Local and systemic effects of an allogeneic tumor cell vaccine combining transgenic human lymphotactin with interleukin-2 in patients with advanced or refractory neuroblastoma

2003 • 120 citations

Dendritic cells delivered inside human carcinomas are sequestered by interleukin‐8

2005 • 118 citations

Generation of Th1 and Th2 Chemokines by Human Eosinophils: Evidence for a Critical Role of TNF-α

2007 • 117 citations

Chemokine receptor dimerization: two are better than one

2001 • 115 citations

Plasmacytoid Dendritic Cell Recruitment by Immobilized CXCR3 Ligands

2004 • 115 citations

IFN-γ-Inducible Protein-10 Is Essential for the Generation of a Protective Tumor-Specific CD8 T Cell Response Induced by Single-Chain IL-12 Gene Therapy

2001 • 113 citations

PREFERENTIAL EXPRESSION OF CHEMOKINE RECEPTOR CXCR4 BY HIGHLY MALIGNANT HUMAN GLIOMAS AND ITS ASSOCIATION WITH POOR PATIENT SURVIVAL

2007 • 112 citations

RANTES expression is a predictor of survival in stage I lung adenocarcinoma.

2002 • 110 citations

Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes

2003 • 107 citations

Helper role of NK cells during the induction of anticancer responses by dendritic cells

2004 • 107 citations

Didox (A Novel Ribonucleotide Reductase Inhibitor) Overcomes bcl-2 Mediated Radiation Resistance in Prostate Cancer Cell Line PC-3

2002 • 101 citations

CXCR3-mediated opposite effects of CXCL10 and CXCL4 on T1 or T2 cytokine production

2005 • 101 citations

The neutrophil-activating protein ofHelicobacter pylori(HP-NAP) as an immune modulating agent

2007 • 100 citations

Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer

2007 • 98 citations

Matrix metalloproteinase-9 is up-regulated by CCL21/CCR7 interaction via extracellular signal-regulated kinase-1/2 signaling and is involved in CCL21-driven B-cell chronic lymphocytic leukemia cell invasion and migration

2007 • 96 citations

Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a

2007 • 96 citations

Favorable prognosis of renal cell carcinoma with increased expression of chemokines associated with a Th1‐type immune response

2006 • 94 citations

Up-Regulation of Functional Chemokine Receptor CCR3 in Human Renal Cell Carcinoma

2005 • 92 citations

Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells.

2007 • 91 citations

Eotaxin-3/CCL26 Is a Natural Antagonist for CC Chemokine Receptors 1 and 5

2004 • 90 citations

Potent Antiviral Synergy between Monoclonal Antibody and Small-Molecule CCR5 Inhibitors of Human Immunodeficiency Virus Type 1

2006 • 89 citations

Intratumoral CC Chemokine Ligand 5 Overexpression Delays Tumor Growth and Increases Tumor Cell Infiltration

2004 • 88 citations

A dual role for tumor-derived chemokine RANTES (CCL5)

2003 • 87 citations

Expression of CCL28 by Reed-Sternberg Cells Defines a Major Subtype of Classical Hodgkin's Disease with Frequent Infiltration of Eosinophils and/or Plasma Cells

2004 • 87 citations

HIGH EXPRESSION OF CHEMOKINE GENE AS A FAVORABLE PROGNOSTIC FACTOR IN RENAL CELL CARCINOMA

2004 • 86 citations

Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma

2003 • 86 citations

Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells

2005 • 83 citations

CXCR3 and its binding chemokines in myeloma cells: expression of isoforms and potential relationships with myeloma cell proliferation and survival.

2006 • 81 citations

Significant differences of lymphocytes isolated from ascites of patients with ovarian cancer compared to blood and tumor lymphocytes. Association of CD3+CD56+ cells with platinum resistance

2007 • 77 citations

Eosinophils are the major source of transforming growth factor-beta 1 in nodular sclerosing Hodgkin's disease.

1993 • 77 citations

Transendothelial Migration of Myeloma Cells Is Increased by Tumor Necrosis Factor (TNF)-α via TNF Receptor 2 and Autocrine Up-Regulation of MCP-1

2004 • 75 citations

Antitumor Activity of Eosinophils Activated by IL-5 and Eotaxin against Hepatocellular Carcinoma

2004 • 75 citations

Chemokines in cancer

2001 • 70 citations

Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity

2001 • 70 citations

CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23+CD5+ B Cells

2006 • 70 citations

Monocyte Chemoattractant Protein-1 Selectively Inhibits the Acquisition of CD40 Ligand-Dependent IL-12-Producing Capacity of Monocyte-Derived Dendritic Cells and Modulates Th1 Immune Response

2002 • 70 citations

Fractalkine (CX3CL1)– and Interleukin-2–Enriched Neuroblastoma Microenvironment Induces Eradication of Metastases Mediated by T Cells and Natural Killer Cells

2007 • 69 citations

Breast Cancer Progression and Host Polymorphisms in the Chemokine System: Role of the Macrophage Chemoattractant Protein-1 (MCP-1) −2518 G Allele

2005 • 65 citations

Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T-cell responses

2006 • 63 citations

Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.

2003 • 60 citations

Lung adenocarcinoma invasion in TGFβRII-deficient cells is mediated by CCL5/RANTES

2007 • 60 citations

Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma

2007 • 59 citations

Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1

2003 • 57 citations

Chemokine Receptor Desensitization in Tumor-Bearing Mice

2001 • 56 citations

I-TAC/CXCL11 is a natural antagonist for CCR5

2004 • 56 citations

Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia

2007 • 55 citations

Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo

2004 • 54 citations

Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.

2002 • 54 citations

Enhancement of the anti-leukemic activity of cytokine induced killer cells with an anti-CD19 chimeric receptor delivering a 4-1BB-ζ activating signal

2007 • 50 citations

Monocyte chemoattractant protein inhibits the generation of tumor-reactive T cells.

1997 • 49 citations

Phase I Trial of Vaccination With Autologous Neuroblastoma Tumor Cells Genetically Modified to Secrete IL-2 and Lymphotactin

2007 • 47 citations

CC‐chemokine ligand 17 gene therapy induces tumor regression through augmentation of tumor‐infiltrating immune cells in a murine model of preexisting CT26 colon carcinoma

2007 • 46 citations

Correlations between Serum Monocyte Chemotactic Protein-1 Levels, Clinical Prognostic Factors, and HER-2/neu Vaccine-Related Immunity in Breast Cancer Patients

2006 • 43 citations

Clinical utilization of chemokines to combat cancer: the double-edged sword

2007 • 39 citations

Therapeutics targeting tumor immune escape: Towards the development of new generation anticancer vaccines

2007 • 39 citations

Mitogenic effects of interleukin-8/CXCL8 on cancer cells

2005 • 39 citations

Modulation of dendritic cell phenotype and mobility by tumor cells in vitro

2001 • 39 citations

Desensitization of T lymphocyte function by CXCR3 ligands in human hepatocellular carcinoma

2005 • 37 citations

Intralesional Injection of Adenovirus Encoding CC Chemokine Ligand 16 Inhibits Mammary Tumor Growth and Prevents Metastatic-Induced Death after Surgical Removal of the Treated Primary Tumor

2004 • 36 citations

CCL19 (ELC) as an adjuvant for DNA vaccination: induction of a TH1-type T-cell response and enhancement of antitumor immunity

2007 • 36 citations

Chemokine gene modification of human dendritic cell-based tumor vaccines using a recombinant adenoviral vector

2004 • 35 citations

Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia

2006 • 35 citations

Therapy-Induced Tumor Immunosurveillance Involves IFN-Producing Killer Dendritic Cells

2007 • 35 citations

Synergistic antitumor effect by coexpression of chemokine CCL21/SLC and costimulatory molecule LIGHT

2004 • 30 citations

Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Induces Dendritic Cell Maturation and Function

2005 • 23 citations

In situ expression of IFN-γ-inducible T cell α chemoattractant in breast cancer mounts an enhanced specific anti-tumor immunity which leads to tumor regression

2007 • 22 citations

Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer

2007 • 21 citations

Down-Modulation of CXCR3 Surface Expression and Function in CD8+ T Cells from Cutaneous T Cell Lymphoma Patients

2007 • 20 citations

Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs

2006 • 16 citations

IL‐8 enhances antibody‐dependent cellular cytotoxicity in human neutrophils

1995 • 14 citations

Intratumoral Expression of Macrophage-Derived Chemokine Induces CD4+ T Cell-Independent Antitumor Immunity in Mice

2003 • 12 citations

More than chemotaxis: A new anti-tumor DC vaccine modified by rAAV2-SLC

2007 • 10 citations

Functional and Molecular Alterations in T Cells Induced by CCL5

2006 • 7 citations

A chemotactic factor for rat thymocytes may regulate T-lymphocyte migration toward the thymic microenvironment

1987 • 7 citations