Back to search

Reduced Skeletal Muscle Inhibitor of κBβ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes

Data up to Jan 2025

Published2006
Citations145
References55

Total Citations Per Year

Abstract

References (55)

Free Radicals in the Physiological Control of Cell Function

2002 • 9,561 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

2002 • 2,164 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*

1959 • 1,674 citations

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

2002 • 1,345 citations

IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

2004 • 1,267 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

2000 • 1,119 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes

2001 • 1,074 citations

Is Type II diabetes mellitus a disease of the innate immune system?

1998 • 1,040 citations

The molecular basis of skeletal muscle atrophy

2004 • 973 citations

The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

2000 • 927 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

2002 • 742 citations

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

1996 • 727 citations

Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

1988 • 713 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

2004 • 647 citations

IκB kinases: key regulators of the NF-κB pathway

2004 • 618 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 614 citations

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

1999 • 590 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 529 citations

Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans

2001 • 454 citations

Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance

2003 • 447 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner

2004 • 404 citations

Skeletal muscle lipid metabolism with obesity

2003 • 333 citations

Acute exercise activates nuclear factor (NF)‐ΚB signaling pathway in rat skeletal muscle

2004 • 274 citations

Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle

2000 • 274 citations

Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473

2000 • 268 citations

Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases

2003 • 254 citations

Molecular mechanisms of interleukin-10-mediated inhibition of NF-κB activity: a role for p50

2003 • 254 citations

AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells

2004 • 233 citations

Ceramide impairs the insulin-dependent membrane recruitment of Protein Kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells

2001 • 231 citations

Suppression of Nuclear Factor-κB and Stimulation of Inhibitor κB by Troglitazone: Evidence for an Anti-inflammatory Effect and a Potential Antiatherosclerotic Effect in the Obese

2001 • 225 citations

Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFα

1994 • 219 citations

Fatty Acid-induced Insulin Resistance in L6 Myotubes Is Prevented by Inhibition of Activation and Nuclear Localization of Nuclear Factor κB

2004 • 215 citations

Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the TNF Promoter Region

2000 • 206 citations

Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects

2004 • 205 citations

Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle

2005 • 201 citations

Use of intramuscular triacylglycerol as a substrate source during exercise in humans

2004 • 190 citations

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM

1988 • 184 citations

Inhibition of Tumor Necrosis Factor-α Improves Physiological Angiogenesis and Reduces Pathological Neovascularization in Ischemic Retinopathy

2005 • 172 citations

Muscle Long‐Chain Acyl CoA Esters and Insulin Resistance

2002 • 138 citations

Regulation of IκB kinase and NF-κB in contracting adult rat skeletal muscle

2005 • 122 citations

Insulin Resistance as a Proinflammatory State: Mechanisms, Mediators, and Therapeutic Interventions

2003 • 93 citations

The p50-p50 NF-κB complex as a stimulus-specific repressor of gene activation

2004 • 79 citations

Diet-induced obesity and acute hyperlipidemia reduce IκBα levels in rat skeletal muscle in a fiber-type dependent manner

2005 • 66 citations

Fatiguing exercise reduces DNA binding activity of NF-κB in skeletal muscle nuclei

2004 • 65 citations

Effect of low-protein diet and protein supplementation on the expressions of TNF-α, TNFR-I, and TNFR-II in organs and muscle of LPS-injected rats

2004 • 32 citations

Inflammatory response associated with pulmonary complications in non-HIV immunocompromised patients

2004 • 24 citations

The Link Between Insulin Resistance Syndrome and Inflammatory Markers

2003 • 6 citations

Cited By (0)

Loading...