GRP94 (gp96) and GRP94 N-Terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression

Antibodies, a laboratory manual

1989 • 12,929 citations

Innate Immune Recognition

2002 • 8,157 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo

1999 • 1,066 citations

Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses

2002 • 845 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

2000 • 561 citations

Role of NK cells in tumour growth and metastasis in beige mice

1980 • 524 citations

The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway

2002 • 496 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

1999 • 413 citations

Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells

1999 • 399 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Cross-Presentation of Glycoprotein 96–Associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-Mediated Endocytosis

1999 • 352 citations

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

2001 • 349 citations

A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas

2002 • 347 citations

Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake

1999 • 332 citations

The Anti-Tumor Activity of IL-12: Mechanisms of Innate Immunity That Are Model and Dose Dependent

2000 • 304 citations

Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity

2002 • 277 citations

Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide.

1999 • 264 citations

Cutting Edge: Inhibition of Experimental Tumor Metastasis by Dendritic Cells Pulsed with α-Galactosylceramide

1999 • 230 citations

Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.

1995 • 222 citations

Stress-Induced Proteins in Immune Response to Cancer

1991 • 179 citations

TAP‐translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin

1997 • 171 citations

Cell Surface Targeting of Heat Shock Protein gp96 Induces Dendritic Cell Maturation and Antitumor Immunity

2001 • 161 citations

HSP70 peptide-bearing and peptide-negative preparations act as chaperokines

2000 • 159 citations

Heat Shock Protein Vaccines Against Cancer

1993 • 156 citations

In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is Cd4+ T Cell Independent

2000 • 125 citations

Cutting Edge: Tumor Secreted Heat Shock-Fusion Protein Elicits CD8 Cells for Rejection

1999 • 121 citations

Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages

1999 • 105 citations

In Vivo and In Vitro Activation of T Cells After Administration of Ag-Negative Heat Shock Proteins

1999 • 99 citations

Different sorting of Lys-Asp-Glu-Leu proteins in rat liver.

1992 • 89 citations

Identification of the Peptide-binding Site in the Heat Shock Chaperone/Tumor Rejection Antigen gp96 (Grp94)

2000 • 77 citations

Transfer of GRP94(Gp96)‐Associated Peptides onto Endosomal MHC Class I Molecules

2002 • 75 citations

Endoplasmic Reticulum Chaperone GRP94 Subunit Assembly Is Regulated through a Defined Oligomerization Domain

1996 • 74 citations

Ligand Interactions in the Adenosine Nucleotide-binding Domain of the Hsp90 Chaperone, GRP94

2000 • 72 citations

Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells

2001 • 71 citations

Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene.

1988 • 62 citations

ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection

2003 • 60 citations

Protein disulfide isomerase is the dominant acceptor for peptides translocated into the endoplasmic reticulum

1997 • 54 citations

Purification and Partial Molecular Characterization of GRP94, an ER Resident Chaperone

1996 • 53 citations

Ligand Interactions in the Adenosine Nucleotide-binding Domain of the Hsp90 Chaperone, GRP94

2000 • 53 citations

Minor Histocompatibility Antigen-Specific MHC-Restricted CD8 T Cell Responses Elicited by Heat Shock Proteins

2002 • 50 citations

GRP94-associated Enzymatic Activities

2002 • 38 citations

IMMUNOTHERAPY OF TUMORS WITH AUTOLOGOUS TUMORDERIVED HEAT SHOCK PROTEIN PREPARATIONS

1997 • 37 citations

Chapter 1 Why Purify Enzymes?

2009 • 32 citations

Treatment of established lung metastases with tumor-infiltrating lymphocytes derived from a poorly immunogenic tumor engineered to secrete human TNF-alpha.

1994 • 28 citations

[1] Why purify enzymes?

1990 • 25 citations

Activation of cytotoxic T cells in vitro by recombinant gp96 fusion proteins irrespective of the 'fused' antigenic peptide sequence

1999 • 19 citations

Structure and Folding of Nascent Polypeptide Chains during Protein Translocation in the Endoplasmic Reticulum

1997 • 18 citations