Identification of the Peptide-binding Site in the Heat Shock Chaperone/Tumor Rejection Antigen gp96 (Grp94)

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Multiple sequence alignment with hierarchical clustering

1988 • 5,250 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

Bioconjugate techniques

1997 • 642 citations

Heat shock protein 70-associated peptides elicit specific cancer immunity.

1993 • 631 citations

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

1997 • 567 citations

Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

1998 • 560 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells

1999 • 399 citations

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

1994 • 363 citations

[15] Cleavage at aspartylprolyl bonds

1977 • 319 citations

Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

1992 • 295 citations

ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

1987 • 294 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

Calreticulin, a Peptide-binding Chaperone of the Endoplasmic Reticulum, Elicits Tumor- and Peptide-specific Immunity

1999 • 252 citations

Isolation of MHC Class I-Restricted Tumor Antigen Peptide and Its Precursors Associated with Heat Shock Proteins hsp70, hsp90, and gp96

1999 • 239 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

Immunization with a Lymphocytic Choriomeningitis Virus Peptide Mixed with Heat Shock Protein 70 Results in Protective Antiviral Immunity and Specific Cytotoxic T Lymphocytes

1998 • 193 citations

Stress-Induced Proteins in Immune Response to Cancer

1991 • 179 citations

TAP‐translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin

1997 • 171 citations

Heat Shock Protein Vaccines Against Cancer

1993 • 156 citations

The Dual Nature of Specific Immunological Activity of Tumor-derived gp96 Preparations

1999 • 137 citations

Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96

1998 • 130 citations

The endoplasmic reticulum‐resident stress protein gp96 binds peptides translocated by TAP

1997 • 117 citations

Interaction of Endoplasmic Reticulum Chaperone GRP94 with Peptide Substrates Is Adenine Nucleotide-independent

1997 • 115 citations

Peptide-Mass Profiles of Polyvinylidene Difluoride-Bound Proteins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry in the Presence of Nonionic Detergents

1996 • 113 citations

Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation?

1991 • 105 citations

Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides

1997 • 89 citations

Influences of Transporter Associated with Antigen Processing (TAP) on the Repertoire of Peptides Associated with the Endoplasmic Reticulum–resident Stress Protein gp96

1997 • 85 citations

Heat shock protein–peptide complexes as immunotherapy for human cancer

1998 • 84 citations

Endoplasmic Reticulum Chaperone GRP94 Subunit Assembly Is Regulated through a Defined Oligomerization Domain

1996 • 74 citations

Synthetic peptides non‐covalently bound to bacterial hsp 70 elicit peptide‐specific T‐cell responses in vivo

1996 • 74 citations

5'-structural analysis of genes encoding polymorphic antigens of chemically induced tumors.

1987 • 68 citations

Generation of Tumor-Specific Cytotoxic T Lymphocytes and Memory T Cells by Immunization with Tumor-Derived Heat Shock Protein gp96

1998 • 62 citations

Purification and Partial Molecular Characterization of GRP94, an ER Resident Chaperone

1996 • 53 citations

Molecular chaperones in the etiology and therapy of cancer

1998 • 44 citations

Molecular Mechanisms of Peptide Loading by the Tumor Rejection Antigen/Heat Shock Chaperone gp96 (GRP94)

1999 • 40 citations