Ligand Interactions in the Adenosine Nucleotide-binding Domain of the Hsp90 Chaperone, GRP94

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Analysis of Molecular Masses and Oligomeric States of Protein Complexes by Blue Native Electrophoresis and Isolation of Membrane Protein Complexes by Two-Dimensional Native Electrophoresis

1994 • 1,211 citations

The 90-kDa Molecular Chaperone Family

1998 • 1,008 citations

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

1999 • 979 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Synthesis and spectral properties of a hydrophobic fluorescent probe: 6-propionyl-2-(dimethylamino)naphthalene

1979 • 811 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

GHKL, an emergent ATPase/kinase superfamily

2000 • 725 citations

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo

1998 • 709 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

Properties of graphical representations of multiple classes of binding sites

1971 • 616 citations

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

1998 • 584 citations

Heat shock proteins transfer peptides during antigen processing and CTL priming

1994 • 580 citations

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

1997 • 567 citations

Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

1998 • 560 citations

Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins

1998 • 525 citations

Spectrofluorimetric assessment of the surface hydrophobicity of proteins

1992 • 465 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

Mammalian stress response: induction of the glucose-regulated protein family

1992 • 452 citations

The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors

1998 • 444 citations

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1994 • 430 citations

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1999 • 411 citations

The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications

1994 • 391 citations

Transient Interaction of Hsp90 with Early Unfolding Intermediates of Citrate Synthase

1995 • 365 citations

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

1994 • 363 citations

Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

1995 • 339 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

1998 • 272 citations

p185erbB2 Binds to GRP94 in Vivo

1996 • 259 citations

Calreticulin, a Peptide-binding Chaperone of the Endoplasmic Reticulum, Elicits Tumor- and Peptide-specific Immunity

1999 • 252 citations

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

1993 • 245 citations

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

1998 • 244 citations

The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains.

1992 • 243 citations

The Assembly of Progesterone Receptor-hsp90 Complexes Using Purified Proteins

1998 • 239 citations

Isolation of MHC Class I-Restricted Tumor Antigen Peptide and Its Precursors Associated with Heat Shock Proteins hsp70, hsp90, and gp96

1999 • 239 citations

Nucleotides and Two Functional States of hsp90

1997 • 238 citations

A Cyclophilin Function in Hsp90-Dependent Signal Transduction

1996 • 233 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

[27] Analysis of chaperone function using citrate synthase as nonnative substrate protein

1998 • 223 citations

Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94.

1996 • 222 citations

In Vivo Analysis of the Hsp90 Cochaperone Sti1 (p60)

1997 • 219 citations

Dimer formation from 1-anilino-8-naphthalenesulfonate catalyzed by bovine serum albumin. Fluorescent molecule with exceptional binding properties

1969 • 213 citations

Interactions of p60, a mediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp70.

1996 • 212 citations

Heat-induced Chaperone Activity of HSP90

1996 • 194 citations

Statistical Time Events in Enzymes: A Physical Assessmen

1975 • 194 citations

Hsp90's secrets unfold: new insights from structural and functional studies

1999 • 181 citations

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides.

1989 • 176 citations

The Role of DnaJ-like Proteins in Glucocorticoid Receptor·hsp90 Heterocomplex Assembly by the Reconstituted hsp90·p60·hsp70 Foldosome Complex

1998 • 168 citations

Interaction of Radicicol with Members of the Heat Shock Protein 90 Family of Molecular Chaperones

1999 • 153 citations

Proteins under extreme physical conditions

1990 • 151 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Biochemical Methods for Analysis of Histone Deacetylases

1998 • 147 citations

The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

1991 • 147 citations

Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain

1997 • 145 citations

ATP induces a conformational change of the 90-kDa heat shock protein (hsp90).

1993 • 133 citations

Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96

1998 • 130 citations

Identification of 1,1′-Bi(4-anilino)naphthalene-5,5′-disulfonic Acid Binding Sequences in α-Crystallin

1998 • 122 citations

Protein Conformational Changes Induced by 1,1'-Bis(4-anilino-5-naphthalenesulfonic acid): Preferential Binding to the Molten Globule of DnaK

1994 • 117 citations

Interaction of Endoplasmic Reticulum Chaperone GRP94 with Peptide Substrates Is Adenine Nucleotide-independent

1997 • 115 citations

Calreticulin Displays In Vivo Peptide-Binding Activity and Can Elicit CTL Responses Against Bound Peptides

1999 • 110 citations

ATP-binding Properties of Human Hsp90

1997 • 107 citations

Two FKBP-related proteins are associated with progesterone receptor complexes.

1993 • 106 citations

Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation.

1994 • 104 citations

Stress proteins and immunity mediated by cytotoxic T lymphocytes

1999 • 103 citations

Ra Adenosine receptors in human platelets

1984 • 102 citations

Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway

1998 • 101 citations

Assessment of the ATP Binding Properties of Hsp90

1996 • 98 citations

Isolation of processed, H-2Kb -binding ovalbumin-derived peptides associated with the stress proteins HSP70 and GP96

1998 • 96 citations

Autophosphorylation of grp94 (Endoplasmin)

1995 • 80 citations

The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes

1996 • 79 citations

Endoplasmic Reticulum Chaperone GRP94 Subunit Assembly Is Regulated through a Defined Oligomerization Domain

1996 • 74 citations

Association of Hsp47, Grp78, and Grp94 with procollagen supports the successive or coupled action of molecular chaperones

1994 • 72 citations

Ligand Interactions in the Adenosine Nucleotide-binding Domain of the Hsp90 Chaperone, GRP94

2000 • 72 citations

Structural Transitions Accompanying the Activation of Peptide Binding to the Endoplasmic Reticulum Hsp90 Chaperone GRP94

1998 • 61 citations

Purification and Partial Molecular Characterization of GRP94, an ER Resident Chaperone

1996 • 53 citations

A mutation in the ectodomain of herpes simplex virus 1 glycoprotein B causes defective processing and retention in the endoplasmic reticulum

1991 • 52 citations

Reversible Oligomerization and Denaturation of the Chaperonin GroES

1996 • 50 citations

Soluble and membrane-associated human low-affinity adenosine binding protein (adenotin): properties and homology with mammalian and avian stress proteins

1990 • 49 citations

Heat-induced Oligomerization of the Molecular Chaperone Hsp90

1999 • 49 citations

Purification and characterization of the adenosine A2-like binding site from human placental membrane

1989 • 48 citations

GRP94 (endoplasmin) co‐purifies with and is phosphorylated by Golgi apparatus casein kinase

2000 • 46 citations

Glycerol as an agent eliciting small conformational changes in alcohol dehydrogenase.

1975 • 45 citations

Heat shock protein-peptide complexes for use in vaccines

1996 • 44 citations

4,4'-Bis (1-anilinonaphthalene 8-sulfonate) (bis-ANS): a new probe of the active site of myosin.

1977 • 43 citations

Molecular Mechanisms of Peptide Loading by the Tumor Rejection Antigen/Heat Shock Chaperone gp96 (GRP94)

1999 • 40 citations

Binding characteristics of an adenosine receptor in human placenta.

1983 • 35 citations

Essential Dynamics from NMR Clusters: Dynamic Properties of the Myb DNA-Binding Domain and a Hinge-Bending Enhancing Variant

1998 • 34 citations

Dimerization Characteristics of the 94-kDa Glucose-Regulated Protein

1996 • 34 citations

Hsp47 and Other ER-Resident Molecular Chaperones Form Heterocomplexes with Each Other and with Collagen Type IV Chains

1996 • 32 citations

Fluorescence studies of nucleotide interactions with bovine adrenal chromogranin A

1990 • 29 citations

The effect of extracellular Ca2+ and temperature on the induction of the heat-shock and glucose-regulated proteins in hamster fibroblasts

1986 • 29 citations

A predicted consensus structure for the N-Terminal fragment of the heat shock protein HSP90 family

1997 • 26 citations

Endoplasmic reticulum stress-inducible protein GRP94 is associated with an Mg2+-dependent serine kinase activity modulated by Ca2+ and GRP78/BiP

1997 • 26 citations

Association of protein kinase CK2 with eukaryotic translation initiation factor eIF-2 and with grp94/endoplasmin

1999 • 25 citations

[26] Photoincorporation of fluorescent probe into GroEL: Defining site of interaction

1998 • 11 citations