ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection

Innate Immune Recognition

2002 • 8,157 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo

1999 • 1,066 citations

Roles of heat-shock proteins in innate and adaptive immunity

2002 • 1,037 citations

Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses

2002 • 845 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Hsp90

2001 • 819 citations

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

2001 • 800 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

An innate sense of danger

1998 • 752 citations

Trojan peptides: the penetratin system for intracellular delivery

1998 • 707 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

Heat-shock proteins as activators of the innate immune system

2002 • 579 citations

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

1997 • 567 citations

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

2000 • 561 citations

The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway

2002 • 496 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

Cross-Presentation of Glycoprotein 96–Associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-Mediated Endocytosis

1999 • 352 citations

A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas

2002 • 347 citations

Common and divergent peptide binding specificities of hsp70 molecular chaperones.

1994 • 283 citations

Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity

2002 • 277 citations

Delineation of mRNA Export Pathways by the Use of Cell-Permeable Peptides

2001 • 266 citations

Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo

2001 • 260 citations

Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs

2002 • 258 citations

Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo

2000 • 223 citations

Trojan peptides: the penetratin system for intracellular delivery

1998 • 174 citations

TAP‐translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin

1997 • 171 citations

HSP70 peptide-bearing and peptide-negative preparations act as chaperokines

2000 • 159 citations

Heat Shock Protein Vaccines Against Cancer

1993 • 156 citations

Discrete Proteolytic Intermediates in the MHC Class I Antigen Processing Pathway and MHC I–Dependent Peptide Trimming in the ER

1999 • 123 citations

Interaction of Endoplasmic Reticulum Chaperone GRP94 with Peptide Substrates Is Adenine Nucleotide-independent

1997 • 115 citations

Role of Natural Killer Cells in Tumor Growth and Metastasis: C57BL/6 Normal and Beige Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 110 citations

Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation?

1991 • 105 citations

Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages

1999 • 105 citations

Virally Induced Lytic Cell Death Elicits the Release of Immunogenic GRP94/gp96

2001 • 97 citations

Cutting Edge: CD91-Independent Cross-Presentation of GRP94(gp96)-Associated Peptides

2002 • 92 citations

Immunotherapy of bladder cancer

1997 • 87 citations

Transfer of GRP94(Gp96)‐Associated Peptides onto Endosomal MHC Class I Molecules

2002 • 75 citations

Radicicol-sensitive Peptide Binding to the N-terminal Portion of GRP94

2002 • 74 citations

Minor Histocompatibility Antigen-Specific MHC-Restricted CD8 T Cell Responses Elicited by Heat Shock Proteins

2002 • 50 citations

Inhibition of murine bladder tumor growth by bacille Calmette-Guerin: Lack of a role of natural killer cells

1986 • 43 citations

GRP94-associated Enzymatic Activities

2002 • 38 citations

Chapter 1 Why Purify Enzymes?

2009 • 32 citations

[1] Why purify enzymes?

1990 • 25 citations

Differential Inhibition of Hsc70 Activities by Two Hsc70-Binding Peptides

2002 • 19 citations

The immunological properties of endoplasmic reticulum chaperones: a conflict of interest?

2000 • 14 citations