Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.

Basic Methods in Molecular Biology

1986 • 3,284 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Establishment and identification of small cell lung cancer cell lines having classic and variant features

1986 • 896 citations

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1954 • 861 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.

1985 • 472 citations

Topoisomerase-targeting antitumor drugs

1989 • 441 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

1990 • 222 citations

Chemosensitivity testing of human lung cancer cell lines using the MTT assay

1988 • 207 citations

The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non-small-cell lung cancer.

1989 • 189 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Characterization of an Amsacrine-resistant Line of Human Leukemia Cells

1989 • 179 citations

Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.

1988 • 162 citations

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.

1990 • 157 citations

Dependence of mammalian DNA synthesis on DNA supercoiling. III Characterization of the inhibition of replicative and repair-type DNA synthesis by novobiocin and nalidixic acid

1981 • 96 citations

Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line

1989 • 89 citations

Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.

1987 • 75 citations

DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide

1987 • 73 citations

Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells

1990 • 65 citations

Comparison of dna cleavage induced by etoposide and doxorubicin in two human small‐cell lung cancer lines with different sensitivities to topoisomerase ii inhibitors

1990 • 49 citations

Evidence of DNA topoisomerase II-dependent mechanisms of multidrug resistance in P388 leukemia cells.

1990 • 43 citations

Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417

1989 • 33 citations

Altered expression and transcription of the topoisomerase II gene in nitrogen mustard-resistant human cells

1988 • 26 citations

Correlation of in vitro drug sensitivity testing of long-term small cell lung cancer cell lines with response and survival

1990 • 22 citations

Isolation and partial characterisation of a mammalian cell mutant hypersensitive to topoisomerase II inhibitors and X-rays

1990 • 20 citations

Prediction of the clinical chemotherapeutic response of stage III lung adenocarcinoma patients by an in vitro short term test

1988 • 18 citations

Comparative effects of growth inhibitors on DNA replication, DNA repair, and protein synthesis in human epidermal keratinocytes.

1986 • 14 citations

Relationships among tumor responsiveness, cell sensitivity, doxorubicin cellular pharmacokinetics and drug‐induced DNA alterations in two human small‐cell lung cancer xenografts

1990 • 11 citations

Advances in the Biology of Lung Cancer

1989 • 10 citations