Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma.

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk

1988 • 4,727 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Comparing Radical Mastectomy with Quadrantectomy, Axillary Dissection, and Radiotherapy in Patients with Small Cancers of the Breast

1981 • 1,581 citations

A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

1989 • 1,471 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

1975 • 755 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Microvessel quantitation and prognosis in invasive breast carcinoma

1992 • 566 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections.

1990 • 428 citations

A Randomized Clinical Trial Evaluating Sequential Methotrexate and Fluorouracil in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor-Negative Tumors

1989 • 400 citations

Neuroendocrine components of the bronchopulmonary tract: hyperplasias, dysplasias, and neoplasms.

1983 • 389 citations

Efficacy of Adjuvant Chemotherapy in High-Risk Node-Negative Breast Cancer

1989 • 359 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Log-Logistic Regression Models for Survival Data

1983 • 333 citations

Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma

1993 • 320 citations

Intratumoral microvessel density and L53 protein: Correlation with metastasis in head‐and‐neck squamous‐cell carcinoma

1993 • 314 citations

Prolonged Disease-Free Survival after One Course of Perioperative Adjuvant Chemotherapy for Node-Negative Breast Cancer

1989 • 280 citations

Evaluating the Potential Usefulness of New Prognostic and Predictive Indicators on Node-Negative Breast Cancer Patients

1993 • 250 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

p53 as an Independent Prognostic Marker in Lymph Node-Negative Breast Cancer Patients

1993 • 243 citations

Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer

1993 • 189 citations

Tumor angiogenesis in node-negative breast carcinomas ? relationship with epidermal growth factor receptor, estrogen receptor, and survival

1994 • 176 citations

Production a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum.

1978 • 174 citations

Prognostic significance of peritumoral lymphatic and blood vessel invasion in node-negative carcinoma of the breast.

1990 • 154 citations

Is the relationship between angiogenesis and metastasis in breast cancer real?

1992 • 133 citations

Tumour suppressor gene products, proliferation, and differentiation markers in lung neuroendocrine neoplasms

1992 • 114 citations

Human breast cancer: prognostic significance of the c-erbB-2 oncoprotein compared with epidermal growth factor receptor, DNA ploidy, and conventional pathologic features.

1992 • 103 citations

Peritumoral lymphatic invasion in patients with node-negative mammary duct carcinoma

1992 • 81 citations

Prognostic significance of image morphometric microvessel enumeration in breast carcinoma.

1993 • 81 citations

The Development of Biological Therapies for Breast Cancer

1993 • 49 citations

ANTITUMOR EFFECT OF THE ANGIOGENESIS INHIBITOR AGM-1470 AND ITS COMBINATION EFFECT WITH TAMOXIFEN IN DMBA INDUCED MAMMARY-TUMORS IN RATS

1993 • 34 citations

Chemotherapy in Stage I Breast Cancer

1967 • 15 citations

Immunocytochemical detection of progesterone receptor by monoclonal KD-68 antibody in operable breast cancer: Correlations with biochemical assay, pathological features and cell proliferative rate

1989 • 8 citations