Modelling of the MHC II allele I-A g7 of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this molecule

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

1996 • 2,561 citations

Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization

1985 • 2,441 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

The Murine Autoimmune Diabetes Model: NOD and Related Strains

1992 • 498 citations

The natural history of the major histocompatibility complex

1987 • 468 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

X-Ray Crystal Structure of HLA-DR4 (DRA*0101, DRB1*0401) Complexed with a Peptide from Human Collagen II

1997 • 357 citations

Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice

1987 • 308 citations

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

1998 • 288 citations

Crystal Structure of I-Ak in Complex with a Dominant Epitope of Lysozyme

1998 • 245 citations

Crystal Structures of Two I-Ad–Peptide Complexes Reveal That High Affinity Can Be Achieved without Large Anchor Residues

1998 • 236 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

The Elements of Physical Chemistry

1902 • 203 citations

A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity

1997 • 202 citations

A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

1990 • 190 citations

Extracellular antigen processing and presentation by immature dendritic cells

1999 • 190 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

Induction of Glutamic Acid Decarboxylase 65-Specific Th2 Cells and Suppression of Autoimmune Diabetes at Late Stages of Disease Is Epitope Dependent

1999 • 173 citations

The Elements of Physical Chemistry

1992 • 167 citations

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

1994 • 162 citations

The peptide binding motif of the disease associated HLA‐DQ (α 1* 0501, β 1* 0201) molecule

1996 • 160 citations

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.

1993 • 146 citations

Autoreactivity of T cells from nonobese diabetic mice: An I-A^g7-dependent reaction

1998 • 115 citations

HLA class II region sequences, 1998

1998 • 111 citations

Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection.

1996 • 101 citations

Stable Peptide Binding to MHC Class II Molecule Is Rapid and Is Determined by a Receptive Conformation Shaped by Prior Association with Low Affinity Peptides

1999 • 97 citations

Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH.

1991 • 94 citations

Self peptides isolated from MHC glycoproteins of non-obese diabetic mice.

1994 • 92 citations

A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice

1997 • 90 citations

The role of MHC class II molecules in susceptibility to type I diabetes: Identification of peptide epitopes and characterization of the T cell repertoire

1999 • 90 citations

Polymorphic Amino Acid Variations in HLA-DQ Are Associated With Systematic Physical Property Changes and Occurrence of IDDM

1995 • 89 citations

Breaking self-tolerance in nonobese diabetic mice.

1996 • 88 citations

Unique peptide binding characteristics of the disease-associated DQ(α1 * 0501, β1 * 0201) vs the non-disease-associated DQ(α1 * 0201, β1 * 0202) molecule

1997 • 88 citations

A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-Ak.

1996 • 84 citations

Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens

1997 • 81 citations

Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7

1997 • 81 citations

pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH

1999 • 79 citations

Role of the polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligands.

1994 • 79 citations

Analysis of the Role of Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response

1998 • 76 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1994 • 75 citations

Encephalitogenic epitopes of myelin basic protein, proteolipid protein, myelin oligodendrocyte glycoprotein for experimental allergic encephalomyelitis induction in Biozzi ABH (H-2Ag7) mice share an amino acid motif.

1996 • 71 citations

Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse

1997 • 66 citations

Identification of immunogenic epitopes of GAD 65 presented by A g7 in non-obese diabetic mice

1997 • 61 citations

Autoantigen-Independent Deletion of Diabetogenic CD4+ Thymocytes by Protective MHC Class II Molecules

1999 • 54 citations

Quantitative analysis of T cell activation: role of TCR/ligand density and TCR affinity.

1996 • 49 citations

Characterization of Novel T-cell Epitopes on 65kDa and 67kDa Glutamic Acid Decarboxylase Relevant in Autoimmune Responses in NOD Mice

1998 • 45 citations

The peptide-binding strategy of the MHC class II I-A molecules

1998 • 43 citations

Genetic Control of Autoimmune Diabetes in the NOD Mouse

1995 • 42 citations

The Association of MHC with Autoimmune Diseases: Understanding the Pathogenesis of Autoimmune Diabetes

1998 • 40 citations

Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice.

1998 • 37 citations

T Cells with Multiple Fine Specificities are Used by Non-obese Diabetic (NOD) Mice in the Response to GAD(524–543)

1996 • 33 citations

Biochemical characterization of the human diabetes-associated HLA-DQ8 allelic product: Similarity to the major histocompatibility complex class II I-Ag7 protein of non-obese diabetic mice

1997 • 32 citations

Novel Structural Features of the Human Histocompatibility Molecules HLA-DQ as Revealed by Modeling Based on the Published Structure of the Related Molecule HLA-DR

1996 • 30 citations

The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library

2000 • 30 citations

The Inability of the Nonobese Diabetic Class II Molecule to Form Stable Peptide Complexes Does Not Reflect a Failure to Interact Productively with DM

1998 • 28 citations

Responses of NOD Congenic Mice to a Glutamic Acid Decarboxylase-derived Peptide

1994 • 26 citations

Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM

1995 • 25 citations

Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse

1997 • 24 citations

The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding

1996 • 24 citations

The lack of consensus for I-A^g7-peptide binding motifs: Is there a requirement for anchor amino acid side chains?

1999 • 22 citations

A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes.

1999 • 12 citations

Insights into the chemistry and biology of the I-Ag7 class II molecule

1997 • 11 citations

Spontaneous T-cell proliferation in the non-obese diabetic mouse to a peptide from the unique class II MHC molecule, I-A g7 , which is also protective against the development of autoimmune diabetes

1999 • 11 citations

Development of an I-Ag7-expressing Antigen-presenting Cell Line: Intrinsic Molecular Defect in Compact I-Ag7Dimer Generation

1998 • 8 citations

[32] Modeling of structure of human immunodeficiency virus-1 protease with substrate based on crystal structure of rous sarcoma virus protease

1991 • 7 citations

Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM

1995 • 2 citations