Revisiting Tolerance Induced by Autoantigen in Incomplete Freund’s Adjuvant

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Th1 and Th2 subsets: paradigms lost?

1995 • 482 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Croonian lecture.—On immunity with special reference to cell life

1900 • 427 citations

Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice.

1994 • 384 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses

1999 • 352 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

The mode of action of immunologic adjuvants.

1956 • 298 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

1996 • 270 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

Adjuvant-Guided Type-1 and Type-2 Immunity: Infectious/Noninfectious Dichotomy Defines the Class of Response

1999 • 260 citations

Revisiting and revising suppressor T cells

1992 • 256 citations

B Lymphocytes Producing Demyelinating Autoantibodies: Development and Function in Gene-targeted Transgenic Mice

1998 • 241 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Apoptosis in the nervous system in experimental allergic encephalomyelitis

1991 • 229 citations

Activation of mouse complement by monoclonal mouse antibodies

1981 • 226 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

Women Fight Uphill Battle for Equity

1996 • 213 citations

Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease.

1995 • 203 citations

T‐Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State

1987 • 190 citations

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire

1998 • 188 citations

Manipulation of the Th1/Th2 balance in autoimmune disease

1996 • 186 citations

Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity

2000 • 174 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

Suppressor Cell Control of Unresponsiveness to Experimental Allergic Encephalomyelitis

1975 • 153 citations

Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein.

1989 • 152 citations

The mode of action of mineral-oil emulsion adjuvants on antibody production in mice.

1968 • 152 citations

T-Cell Apoptosis in Inflammatory Brain Lesions

1998 • 146 citations

Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.

1995 • 146 citations

Myelin Oligodendrocyte Glycoprotein Induces Experimental Autoimmune Encephalomyelitis in the “Resistant” Brown Norway Rat: Disease Susceptibility Is Determined by MHC and MHC-Linked Effects on the B Cell Response

1999 • 144 citations

A T Helper Cell 2 (Th2) Immune Response against Non-self Antigens Modifies the Cytokine Profile of Autoimmune T Cells and Protects against Experimental Allergic Encephalomyelitis

1997 • 136 citations

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens

1997 • 134 citations

Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells.

1995 • 127 citations

Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice.

1998 • 126 citations

Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG)

1999 • 114 citations

In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2

1994 • 109 citations

Immunoregulation of Experimental Allergic Encephalomyelitis: Conditions for Induction of Suppressor Cells and Analysis of Mechanism

1977 • 106 citations

Cutting Edge: Antisense Knockdown of Inducible Nitric Oxide Synthase Inhibits Induction of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

1998 • 106 citations

Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: Relative roles of interleukin (IL)-4 and IL-10

1993 • 101 citations

HIGH-RESOLUTION CHARACTERIZATION OF CYTOKINE-PRODUCING ALLOREACTIVITY IN NAIVE AND ALLOGRAFT-PRIMED MICE1,2

1998 • 89 citations

Protective action of the encephalitogen and other basic proteins in experimental allergic encephalomyelitis

1968 • 81 citations

Suppressor T cells prevent experimental autoimmune encephalomyelitis in mice.

1977 • 80 citations

Interleukin‐4 and interleukin‐5 are rarely co‐expressed by human T cells

1995 • 79 citations

Investigation of Myelin/Oligodendrocyte Glycoprotein Membrane Topology

1996 • 77 citations

Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease.

1995 • 75 citations

A matched set of rat/mouse chimeric antibodies. Identification and biological properties of rat H chain constant regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha.

1989 • 60 citations

Shifting T‐cell activation thresholds in autoimmunity and determinant spreading

1998 • 53 citations

Activated non-neural specific T cells open the blood–brain barrier to circulating antibodies

1999 • 47 citations

Induction of antibody synthesis by CD4⁺ T cells: IL 5 is essential for induction of antigen‐specific antibody responses by T_H2 but not T_H1 clones

1990 • 44 citations

Antibody-mediated clearance of viruses from the mammalian central nervous system

1993 • 42 citations

The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope

1999 • 42 citations

Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease.

1991 • 37 citations

Protection against Experimental Allergic Encephalomyelitis with Peptides Derived from Myelin Basic Protein: Presence of Intact Encephalitogenic Site Is Essential

1976 • 36 citations

Analysis of cytokine patterns produced by individual CD4+ lymph node cells during experimental murine leishmaniasis in resistant and susceptible mice.

1998 • 36 citations

Induction of tolerance to one determinant on a synthetic peptide does not affect the response to a second linked determinant. Implications for the mechanism of neonatal tolerance induction.

1986 • 34 citations

Strain Variation in Autoimmunity: Attempted Tolerization of DA Rats Results in the Induction of Experimental Autoimmune Encephalomyelitis

1999 • 33 citations

Immunoregulation in experimental interstitial nephritis: immunization with renal tubular antigen in incomplete Freund's adjuvant induces major histocompatibility complex-restricted, OX8+ suppressor T cells which are antigen-specific and inhibit the expression of disease.

1986 • 31 citations

Specific T-cell tolerance may reflect selective activation of lymphokine synthesis.

1995 • 29 citations

Cure of Progressive Murine Leishmaniasis: Interleukin 4 Dominance Is Abolished by Transient CD4+ T Cell Depletion and T Helper Cell Type 1–selective Cytokine Therapy

1999 • 27 citations

The Fate of T Cells in the Brain

1998 • 27 citations

Molecular analysis of the helper T cell response in murine interstitial nephritis. T cells recognizing an immunodominant epitope use multiple T cell receptor V beta genes with similarities across CDR3.

1994 • 20 citations

Segregation of type 1 cytokine production in human peripheral blood lymphocytes: phenotypic differences between IFN-γ and IL-2-producing cells in the CD8+ T cell subset

1998 • 20 citations

Murine interstitial nephritis. IX. Induction of the nephritogenic effector T cell repertoire with an antigen-specific T cell cytokine.

1990 • 18 citations

Comparisons of organ-specific antigens of the central nervous system.

1969 • 4 citations