Protein Tyrosine Phosphatase 1B Antagonizes Signalling by Oncoprotein Tyrosine Kinase p210 bcr-abl In Vivo

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

1997 • 811 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

1995 • 575 citations

Purification of the major protein-tyrosine-phosphatases of human placenta.

1988 • 564 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

From Form to Function: Signaling by Protein Tyrosine Phosphatases

1996 • 526 citations

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast

1995 • 474 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling

1996 • 424 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

Structural and Signaling Requirements for BCR-ABL-Mediated Transformation and Inhibition of Apoptosis

1995 • 282 citations

Protein Phosphorylation; A Practical Approach

1994 • 273 citations

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

1996 • 271 citations

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

1995 • 268 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

1996 • 259 citations

Osmotic Loading of Neutralizing Antibodies Demonstrates a Role for Protein-tyrosine Phosphatase 1B in Negative Regulation of the Insulin Action Pathway

1995 • 224 citations

Cloning of a cDNA for a major human protein-tyrosine-phosphatase.

1990 • 223 citations

Cloning and expression of a protein-tyrosine-phosphatase.

1990 • 215 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

Insulin action impaired by deficiency of the G-protein subunit Giα2

1996 • 210 citations

Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase.

1987 • 194 citations

Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells.

1996 • 185 citations

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.

1989 • 180 citations

bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.

1988 • 177 citations

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

1992 • 176 citations

Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.

1990 • 174 citations

Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.

1995 • 145 citations

COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus.

1995 • 141 citations

Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism

1994 • 140 citations

Crkl Is Complexed with Tyrosine-phosphorylated Cbl in Ph-positive Leukemia

1995 • 129 citations

Structure and function of SH2-domain containing tyrosine phosphatases

1993 • 118 citations

Association of the T-cell Protein Tyrosine Phosphatase with Nuclear Import Factor p97

1997 • 118 citations

Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.

1992 • 111 citations

Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclin-dependent kinases.

1997 • 108 citations

Increased expression of specific protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the neu oncogene.

1993 • 105 citations

Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B.

1993 • 99 citations

SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.

1994 • 90 citations

Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line.

1993 • 89 citations

Incidence of involvement of the B and T lymphocyte lineages in chronic myelogenous leukemia

1985 • 88 citations

Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.

1995 • 77 citations

Purification and characterization of a human recombinant T-cell protein-tyrosine-phosphatase from a baculovirus expression system

1991 • 71 citations

In Vivo Association of v-Abl with Shc Mediated by a Non-phosphotyrosine-dependent SH2 Interaction

1996 • 65 citations

PI 3-kinase activation in BCR/abl-transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl

1996 • 65 citations

Linkage of proliferative and maturational abnormalities in chronic myelogenous leukemia and relevance to treatment.

1993 • 62 citations

Implication of GAP in Ras-Dependent Transactivation of a Polyoma Enhancer Sequence

1992 • 56 citations

p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.

1996 • 55 citations

Inhibition of Bcr Serine Kinase by Tyrosine Phosphorylation

1996 • 52 citations

The BCR-ABL Oncogene Transforms Rat-1 Cells and Cooperates with v-myc

1989 • 50 citations

Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants.

1994 • 18 citations

Transfection of Human Ovarian Cancer Cells with the HER-2/neuReceptor Tyrosine Kinase Induces a Selective Increase in PTP-H1, PTP-1B, and PTP-α Expression

1996 • 17 citations

Over-expression of protein tyrosine phosphatase 1 (PTP1) alters IL-3-dependent growth and tyrosine phosphorylation.

1996 • 12 citations

Two bcr/abl fusion gene products, P210bcr/abl and P190bcr/abl, are equally sensitive to the protein tyrosine phosphatase of mature granulocytes.

1991 • 4 citations

Characterization of protein (tyrosine) phosphatases

1993 • 3 citations