Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G‐strand overhang

Structure and function of telomeres

1991 • 3,524 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

The DNA-dependent protein kinase

1999 • 896 citations

Heterogeneity in telomere length of human chromosomes

1996 • 861 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

1998 • 636 citations

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry

1998 • 561 citations

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

2000 • 546 citations

Telomeres in the mouse have large inter-chromosomal variations in the number of T ₂ AG ₃ repeats

1997 • 490 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

1999 • 462 citations

Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

1999 • 458 citations

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

1998 • 435 citations

Yeast Ku as a Regulator of Chromosomal DNA End Structure

1998 • 432 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

Telomere maintenance is dependent on activities required for end repair of double-strand breaks

1998 • 369 citations

Deletion of Ku86 causes early onset of senescence in mice

1999 • 360 citations

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

1996 • 349 citations

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

1998 • 345 citations

MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks

1999 • 332 citations

Ku is associated with the telomere in mammals

1999 • 321 citations

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1996 • 291 citations

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

1997 • 267 citations

DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.

2000 • 249 citations

The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities

1998 • 245 citations

Ku70

1998 • 231 citations

Telomerase and cancer: revisiting the telomere hypothesis

1996 • 167 citations

Mouse Lymphoma Cells with Different Radiosensitivities

1961 • 155 citations

Ku Binds Telomeric DNA in Vitro

1999 • 134 citations

Telomeres and telomerase

1999 • 99 citations

G-strand overhangs on telomeres in telomerase-deficient mouse cells

1999 • 93 citations

Telomere length, chromatin structure and chromosome fusigenic potential

1997 • 92 citations

Elongated Telomeres inscidMice

1999 • 91 citations

Telomerase and cancer: revisiting the telomere hypothesis

1996 • 85 citations

Assessment of telomere length in hematopoietic interphase cells using in situ hybridization and digital fluorescence microscopy

1998 • 46 citations

Assessment of telomere length in hematopoietic interphase cells using in situ hybridization and digital fluorescence microscopy

1998 • 36 citations