Osteoprotegerin, a Crucial Regulator of Bone Metabolism, Also Regulates B Cell Development and Function

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

1998 • 2,473 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

RANK is essential for osteoclast and lymph node development

1999 • 1,417 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

1998 • 1,177 citations

TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells

1997 • 1,054 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

Isolation of a Novel Cytokine from Human Fibroblasts That Specifically Inhibits Osteoclastogenesis

1997 • 791 citations

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

1998 • 781 citations

Severe Osteoporosis in Mice Lacking Osteoclastogenesis Inhibitory Factor/Osteoprotegerin

1998 • 774 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

How B and T cells talk to each other

1994 • 659 citations

Estrogen Stimulates Gene Expression and Protein Production of Osteoprotegerin in Human Osteoblastic Cells*

1999 • 657 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

TRANCE Is Necessary and Sufficient for Osteoblast-mediated Activation of Bone Resorption in Osteoclasts

1998 • 571 citations

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

1999 • 408 citations

CD22 regulates thymus-independent responses and the lifespan of B cells

1996 • 395 citations

A Newly Identified Member of Tumor Necrosis Factor Receptor Superfamily (TR6) Suppresses LIGHT-mediated Apoptosis

1999 • 370 citations

Transitional B cells are the target of negative selection in the B cell compartment.

1995 • 352 citations

Positive Selection from Newly Formed to Marginal Zone B Cells Depends on the Rate of Clonal Production, CD19, and btk

2000 • 349 citations

TRANCE, a TNF Family Member, Is Differentially Expressed on T Cell Subsets and Induces Cytokine Production in Dendritic Cells

1999 • 323 citations

OPG/FDCR-1, a TNF Receptor Family Member, Is Expressed in Lymphoid Cells and Is Up-Regulated by Ligating CD40

1998 • 304 citations

IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression.

1999 • 273 citations

TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation

1999 • 262 citations

IFN-γ Mediates a Novel Antiviral Activity Through Dynamic Modulation of TRAIL and TRAIL Receptor Expression

1999 • 220 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors

2000 • 187 citations

Estrogen suppresses stromal cell-dependent lymphopoiesis in culture.

1995 • 151 citations

To die or not to die—the quest of the TRAIL receptors

1999 • 150 citations

Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression

1998 • 138 citations

Activity of TNF‐related apoptosis‐inducing ligand (TRAIL) in haematological malignancies

1997 • 124 citations

Sex Hormones as Negative Regulators of Lymphopoiesis

1994 • 116 citations

Signaling thresholds and interclonal competition in preimmune B‐cell selection

1997 • 51 citations

Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis

1998 • 45 citations

Good hope for making osteoporosis a disease of the past

1994 • 9 citations

Tetracycline Fluorescence Incident Photometry

1994 • 2 citations