Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

1991 • 391 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope.

1994 • 306 citations

The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors

1992 • 278 citations

RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.

1994 • 176 citations

Cloning and Characterization of SRP1, a Suppressor of Temperature-Sensitive RNA Polymerase I Mutations, in Saccharomyces cerevisiae

1992 • 175 citations

Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.

1994 • 169 citations

NPI-1, the human homolog of SRP-1, Interacts with influenza virus nucleoprotein

1995 • 156 citations

Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure.

1994 • 128 citations

Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.

1994 • 125 citations