Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

A simple ultraviolet spectrophotometric method for the determination of protein.

1956 • 1,266 citations

Crystalline Dihydropteroylglutamic Acid

1960 • 461 citations

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

1978 • 426 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

The chromosome of bacteriophage T5

1972 • 289 citations

Size heterogeneity in the 3′ end of dihydrofolate reductase messenger RNAs in mouse cells

1980 • 288 citations

Quantitative analysis of high-resolution trypsin-Giemsa bands on human prometaphase chromosomes

1978 • 248 citations

Cytotoxicity of a Factor Isolated From Human Spleen 2

1973 • 225 citations

Structure and genomic organization of the mouse dihydrofolate reductase gene

1980 • 218 citations

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.

1980 • 215 citations

An Isotopic Assay for Thymidylate Synthetase^*

1966 • 212 citations

Radioactive assay for serine transhydroxymethylase

1965 • 209 citations

Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine

1967 • 204 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Identification of a steroid receptor on the surface of Xenopus oocytes by photoaffinity labeling.

1982 • 174 citations

Purification and Properties of Dihydrofolate Reductase from Ehrlich Ascites Carcinoma Cells^*

1965 • 130 citations

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases.

1980 • 100 citations

Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.

1976 • 97 citations

Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.

1979 • 90 citations

Specifically altered metaphase chromosomes in antifolate-resistant Chinese hamster cells that overproduce dihydrofolate reductase

1980 • 88 citations

Multiple forms of human dihydrofolate reductase messenger RNA

1982 • 84 citations

Uptake and metabolism of N 5 -formyltetrahydrofolate by L1210 leukemia cells.

1972 • 82 citations

Purification and Properties of the Formate-activating Enzyme from Erythrocytes

1962 • 75 citations

Satellite DNA in large marker chromosomes of methotrexate-resistant mouse cells

1980 • 72 citations

Activation of dihydrofolic reductase by urea and formamide

1963 • 40 citations

A rapid radiometric assay for dihydrofolate reductase

1978 • 36 citations

Activation of tetrahydrofolate dehydrogenase by certain cations

1962 • 33 citations

Molecular cloning of Chinese hamster dihydrofolate reductase-specific cDNA and the identification of multiple dihydrofolate reductase mRNAs in antifolate-resistant Chinese hamster lung fibroblasts

1981 • 27 citations

Isolation of a homogeneous preparation of human thymidylate synthetase from HeLa cells

1980 • 26 citations

Stimulation of dihydrofolate reductase activity by p-chloromercuribenzoate

1964 • 23 citations

Multiple messenger RNAs for dihydrofolate reductase

1981 • 13 citations

Karyotypic analysis of methotrexate-resistant and sensitive mouse L5178Y cells

1981 • 10 citations