5′ Nucleotide Sequences Influence Serum-Modulated Expression of a Human Dihydrofolate Reductase Minigene

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.

1977 • 2,233 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids

1981 • 489 citations

Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue

1978 • 408 citations

Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA gene

1982 • 356 citations

Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells

1983 • 293 citations

Splicing and the formation of stable RNA

1979 • 274 citations

The functional human dihydrofolate reductase gene.

1984 • 245 citations

Influence of Oxygen and Culture Media on Plating Efficiency of Some Mammalian Tissue Cells

1972 • 228 citations

Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.

1982 • 184 citations

Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle.

1985 • 165 citations

Transformation of mammalian cells with an amplifiable dominant-acting gene.

1980 • 158 citations

Nucleotide sequence surrounding multiple polyadenylation sites in the mouse dihydrofolate reductase gene.

1982 • 146 citations

Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions.

1985 • 145 citations

Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus.

1984 • 131 citations

Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene.

1985 • 124 citations

Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells.

1982 • 121 citations

Analysis of the Mouse dhfr Promoter Region: Existence of a Divergently Transcribed Gene

1985 • 112 citations

Competitive protein binding assay for methotrexate.

1975 • 100 citations

S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells.

1981 • 94 citations

Human dihydrofolate reductase gene organization

1984 • 93 citations

Growth-Dependent Expression of Dihydrofolate Reductase mRNA from Modular cDNA Genes

1983 • 91 citations

"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

1983 • 90 citations

Cell cycle regulation of dihydrofolate reductase mRNA metabolism in mouse fibroblasts.

1980 • 89 citations

Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts.

1979 • 89 citations

Intronless human dihydrofolate reductase genes are derived from processed RNA molecules.

1982 • 88 citations

Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells

1983 • 87 citations

Rescue of a splicing defective mutant by insertion of an heterologous intron

1980 • 85 citations

Multiple forms of human dihydrofolate reductase messenger RNA

1982 • 84 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase

1983 • 74 citations

In vitro and in vivo analysis of the control of dihydrofolate reductase gene transcription in serum‐stimulated mouse fibroblasts

1984 • 70 citations

Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism.

1984 • 67 citations

Preferential localization of variant nucleosomes near the 5'-end of the mouse dihydrofolate reductase gene.

1985 • 66 citations

Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate

1983 • 60 citations

A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA

1983 • 55 citations

Discrete Human Dihydrofolate Reductase Gene Transcripts Present in Polysomal RNA Map with Their 5′ Ends Several Hundred Nucleotides Upstream of the Main mRNA Start Site

1985 • 53 citations

Pharmacologic Principles of Cancer Treatment

1983 • 47 citations

5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells.

1983 • 41 citations

Human dihydrofolate reductase gene is located in chromosome 5 and is unlinked to the related pseudogenes.

1984 • 38 citations

The effect of polyoma virus, serum factors, and dibutyryl cyclic AMP on dihydrofolate reductase synthesis, and the entry of quiescent cells into S phase

1981 • 28 citations

A human dihydrofolate reductase intronless pseudogene with an Alu repetitive sequence: multiple DNA insertions at a single chromosomal site

1984 • 27 citations

Molecular cloning of Chinese hamster dihydrofolate reductase-specific cDNA and the identification of multiple dihydrofolate reductase mRNAs in antifolate-resistant Chinese hamster lung fibroblasts

1981 • 27 citations

Posttranscriptional control of DHFR gene expression during adenovirus 2 infection

1985 • 22 citations

Organization of a Chinese Hamster Ovary Dihydrofolate Reductase Gene Identified by Phenotypic Rescue

1983 • 19 citations

Amplification of a Cloned Chinese Hamster Dihydrofolate Reductase Gene After Transfer into a Dihydrofolate Reductase-Deficient Cell Line

1983 • 18 citations

Expression and Amplification of Engineered Mouse Dihydrofolate Reductase Minigenes

1983 • 18 citations

Inhibition of dihydrofolate reductase gene expression following serum withdrawal or db-cAMP addition in methotrexate-resistant mouse fibroblasts

1982 • 15 citations

Delayed Processing of Dihydrofolate Reductase Heterogeneous Nuclear RNA in Amino Acid-Starved Mouse Fibroblasts

1983 • 10 citations