The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

1987 • 2,266 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Nucleotide sequence of rous sarcoma virus

1983 • 901 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas

1988 • 481 citations

Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein.

1987 • 439 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

1992 • 335 citations

Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I

1990 • 315 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

1982 • 294 citations

Binding of myosin I to membrane lipids

1989 • 287 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

1988 • 223 citations

RAPID TRANSFORMATION OF CELLS BY ROUS SARCOMA VIRUS

1969 • 203 citations

Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.

1990 • 191 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family

1985 • 167 citations

Primary structure of the brain alpha-spectrin [published erratum appears in J Cell Biol 1989 Mar;108(3):following 1175]

1989 • 164 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1991 • 151 citations

Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

1991 • 148 citations

The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.

1987 • 133 citations

Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

1990 • 128 citations

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.

1991 • 127 citations

The heavy chain of Acanthamoeba myosin IB is a fusion of myosin-like and non-myosin-like sequences.

1987 • 125 citations

Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies.

1988 • 121 citations

Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.

1992 • 120 citations

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.

1989 • 96 citations

DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains

1984 • 60 citations

Genetic structure, transforming sequence, and gene product of avian sarcoma virus UR1

1981 • 53 citations

A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene.

1989 • 40 citations

Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src

1992 • 33 citations

Partial nucleotide sequence of Rous sarcoma virus-29 provides evidence that the original Rous sarcoma virus was replication defective

1985 • 24 citations

Membrane association of the transforming protein of avian sarcoma virus UR2 and mutants temperature sensitive for cellular transformation and protein kinase activity

1985 • 21 citations

Comparison of the structural organizations in the 3′-terminal regions of five avian retrovirus strains: RAV 7, RAV 50, 1377, PR-B, and SR-B

1987 • 8 citations