Basal and Physiological Ca2+ Leak from the Endoplasmic Reticulum of Pancreatic Acinar Cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum

1991 • 1,699 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

A protein-conducting channel in the endoplasmic reticulum

1991 • 613 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

Local and global cytosolic Ca2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate

1993 • 488 citations

Spatial and temporal aspects of cellular calcium signaling

1996 • 480 citations

Stimulus‐secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells.

1992 • 433 citations

Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin.

1988 • 427 citations

BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation

1998 • 427 citations

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore

1994 • 338 citations

Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release

1993 • 259 citations

The endoplasmic reticulum as one continuous Ca2+ pool: visualization of rapid Ca2+ movements and equilibration

2000 • 243 citations

STEREOLOGICAL ANALYSIS OF THE GUINEA PIG PANCREAS

1974 • 239 citations

Termination of cytosolic Ca2+ signals: Ca2+ reuptake into intracellular stores is regulated by the free Ca2+ concentration in the store lumen

1998 • 228 citations

Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate

2000 • 187 citations

Protein folding in the ER

1999 • 171 citations

Two functionally distinct cholecystokinin receptors show different modes of action on Ca2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acini. Studies using a new cholecystokinin analog, JMV-180.

1990 • 166 citations

Unique Inactivation Properties of NAADP-sensitive Ca2+ Release

1996 • 163 citations

Drug-induced Ca2+ release from isolated sarcoplasmic reticulum. I. Use of pyrophosphate to study caffeine-induced Ca2+ release.

1987 • 134 citations

Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores

1995 • 126 citations

Inhibition of Translational Initiation by Activators of the Glucose-regulated Stress Protein and Heat Shock Protein Stress Response Systems

1996 • 124 citations

Evidence for aminoacyl-tRNA binding, peptide bond synthesis, and translocase activities in the aminoacyl transfer reaction

1968 • 119 citations

Cholecystokinin is a Satiety Hormone in Humans at Physiological Post-Prandial Plasma Concentrations

1995 • 114 citations

Pharmacologic differentiation between inositol-1,4,5-trisphosphate-induced Ca2+ release and Ca2+- or caffeine-induced Ca2+ release from intracellular membrane systems.

1989 • 111 citations

The Versatility and Complexity of Calcium Signalling

2001 • 99 citations

Intercellular calcium waves in rat pancreatic acini: mechanism of transmission

1996 • 90 citations

ATP regulates calcium leak from agonist‐sensitive internal calcium stores

1996 • 86 citations

The effect of tetracaine on stimulated contractions, sarcoplasmic reticulum Ca²⁺ content and membrane current in isolated rat ventricular myocytes

1998 • 78 citations

Endoplasmic Reticulum-bound Ribosomes Reside in Stable Association with the Translocon following Termination of Protein Synthesis

2002 • 77 citations

Large aqueous channels in membrane vesicles derived from the rough endoplasmic reticulum of canine pancreas or the plasma membrane of Escherichia coli.

1989 • 74 citations

[28] The use of inhibitors in studies of protein synthesis

1974 • 73 citations

Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells

1997 • 62 citations

Roles of the Propeptide and Metal Ions in the Folding and Stability of the Catalytic Domain of Stromelysin (Matrix Metalloproteinase 3)

1996 • 56 citations

The cyclic ADP ribose antagonist 8-NH 2 -cADP-ribose blocks cholecystokinin-evoked cytosolic Ca 2+ spiking in pancreatic acinar cells

1998 • 54 citations

Thapsigargin-induced Ca2+ mobilization in acutely isolated mouse lacrimal acinar cells is dependent on a basal level of Ins(1,4,5)P3 and is inhibited by heparin

1994 • 51 citations

Inhibitors of inositol trisphosphate-induced Ca2+ release from isolated platelet membrane vesicles

1987 • 45 citations

Translocon Pores in the Endoplasmic Reticulum Are Permeable to a Neutral, Polar Molecule

2001 • 39 citations

Imaging of Intracellular Calcium Stores in Individual Permeabilized Pancreatic Acinar Cells

1996 • 38 citations

Compartmentalization of Ca2+ signaling and Ca2+ pools in pancreatic acini. Implications for the quantal behavior of Ca2+ release.

1994 • 37 citations

Kinetics of the non-specific calcium leak from non-mitochondrial calcium stores in permeabilized A7r5 cells

1996 • 25 citations

Rapid heparin-sensitive Ca2+ release following Ca2+-ATPase inhibition in intact HL-60 granulocytes. Evidence for Ins(1,4,5)P3-dependent Ca2+ cycling across the membrane of Ca2+ stores

1994 • 20 citations

Apoaequorin Monitors Degradation of Endoplasmic Reticulum (ER) Proteins Initiated by Loss of ER Ca2+

2000 • 17 citations

Luminal Ca2+ regulates passive Ca2+ efflux from the intracellular stores of hepatocytes

1998 • 14 citations