Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

The PARP superfamily

2004 • 1,377 citations

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

2002 • 1,352 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

2004 • 979 citations

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

2006 • 756 citations

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

2007 • 745 citations

Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1

2002 • 674 citations

Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

1963 • 613 citations

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

2003 • 606 citations

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

2000 • 532 citations

PARP Goes Transcription

2003 • 530 citations

Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361

2004 • 476 citations

Chromatin Loosening by Poly(ADP)-Ribose Polymerase (PARP) at Drosophila Puff Loci

2003 • 437 citations

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

2004 • 395 citations

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

2003 • 331 citations

Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy

2004 • 276 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Inhibition of Poly(ADP-Ribose) Polymerase Enhances Cell Death and Improves Tumor Growth Delay in Irradiated Lung Cancer Models

2007 • 266 citations

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

2006 • 259 citations

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

2006 • 208 citations

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.

2000 • 201 citations

Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.

2003 • 200 citations

Repair of abasic sites in DNA

2003 • 189 citations

Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft

2005 • 172 citations

Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells

2004 • 163 citations

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.

1999 • 160 citations

Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors

2002 • 143 citations

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

2005 • 101 citations

Enhanced polyadenosine diphosphate‐ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma

2001 • 82 citations

Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site

2002 • 82 citations

Enhanced expression of poly(ADP‐ribose) synthetase gene in malignant lymphoma

1991 • 79 citations

Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

2003 • 75 citations

Enhancement of poly‐adenosine diphosphate‐ribosylation in human hepatocellular carcinoma

2000 • 67 citations

Phosphorylated Histone H2AX in Spheroids, Tumors, and Tissues of Mice Exposed to Etoposide and 3-Amino-1,2,4-Benzotriazine-1,3-Dioxide

2004 • 53 citations

ADP‐Ribosylation of Nuclear Proteins in Normal Lymphocytes and in Low‐Grade Malignant Non‐Hodgkin Lymphoma Cells

1980 • 49 citations

Poly(ADP-ribose) synthesis in human cervical cancer cell — Diagnostic cytological usefulness

1981 • 48 citations

Downregulation of Akt1 Inhibits Anchorage-Independent Cell Growth and Induces Apoptosis in Cancer Cells

2001 • 44 citations

Participation of poly(ADP-robose) polymerase in the drug sensitivity in human lung cancer cell lines

1992 • 11 citations

Intrinsic presence of poly (ADP-ribose) is significantly increased in malignant prostate compared to benign prostate cell lines.

2003 • 9 citations

Systemic administration of the PARP inhibitor GPI 15427 increases the anti-tumor activity of temozolomide in melanoma, glioma and lymphoma preclinical models in vivo

2003 • 1 citations