Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

2002 • 1,352 citations

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

2000 • 940 citations

Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse

1999 • 762 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

1998 • 413 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.

1996 • 236 citations

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

1991 • 229 citations

Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.

2003 • 200 citations

Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells

2004 • 163 citations

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.

1999 • 160 citations

Activity of temozolomide in the treatment of central nervous system tumor xenografts.

1995 • 145 citations

Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors

2002 • 143 citations

The basis for current treatment recommendations for malignant gliomas

1994 • 135 citations

Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.

1997 • 132 citations

3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity

1996 • 121 citations

Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart Failure

2004 • 103 citations

Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep

2003 • 101 citations

Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts

1994 • 86 citations

Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site

2002 • 82 citations

Peroxynitrite Production, DNA Breakage, and Poly(ADP-ribose) Polymerase Activation in a Mouse Model of Oxazolone-Induced Contact Hypersensitivity

2001 • 70 citations

Poly(ADP‐ribose) polymerase inhibitor increases growth inhibition and reduces G₂/M cell accumulation induced by temozolomide in malignant glioma cells

2002 • 65 citations

Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase

2004 • 65 citations

Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor

2004 • 62 citations

Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines.

1995 • 51 citations

Antitumor imidazotetrazines. 20. Preparation of the 8-acid derivative of mitozolomide and its utility in the preparation of active antitumor agents

1990 • 42 citations

Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations

2004 • 37 citations

Heterotransplantation of Human Craniopharyngiomas in Athymic “Nude” Mice

1979 • 33 citations

Activation of Poly(ADP-Ribose) Polymerase in Circulating Leukocytes During Myocardial Infarction

2004 • 25 citations

PARP and PARG as novel therapeutic targets

2002 • 10 citations