Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Randomized Phase III Study of Temozolomide Versus Dacarbazine in the Treatment of Patients With Advanced Metastatic Malignant Melanoma

2000 • 1,252 citations

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

1997 • 777 citations

Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

1992 • 483 citations

Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361

2004 • 476 citations

The role of DNA mismatch repair in drug resistance

1998 • 459 citations

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

1998 • 413 citations

Physiology and pathophysiology of poly(ADP‐ribosyl)ation *

2001 • 333 citations

Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism

2001 • 316 citations

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

1995 • 290 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular.

1993 • 222 citations

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.

2000 • 201 citations

Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

2002 • 200 citations

Poly(ADP-Ribose) Polymerase Inhibitors

2003 • 181 citations

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors

1995 • 131 citations

Relation between carcinogenesis, chromatin structure and poly(ADP-ribosylation) (review).

1991 • 114 citations

Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage

1999 • 110 citations

Genomic instability and tolerance to alkylating agents.

1996 • 106 citations

Temozolomide: a novel oral alkylating agent

2001 • 105 citations

O6-Methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

1998 • 88 citations

Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide

1994 • 87 citations

Enhanced polyadenosine diphosphate‐ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma

2001 • 82 citations

Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site

2002 • 82 citations

Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers.

1983 • 62 citations

Determination of temozolomide in human plasma and urine by high-performance liquid chromatography after solid-phase extraction

1995 • 55 citations

Comparison between the DNA precipitation and alkali unwinding assays for detecting DNA strand breaks and cross-links.

1988 • 43 citations

Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers

1991 • 40 citations

Development and Application of a Sensitive and Rapid Immunoassay for the Quantitation of N7-Methyldeoxyguanosine in DNA Samples

2001 • 33 citations

Evaluation of the alkaline comet assay and urinary 3-methyladenine excretion for monitoring DNA damage in melanoma patients treated with dacarbazine and tamoxifen

2000 • 18 citations

Quantitative Nonisotopic Immuno-Dot-Blot Method for the Assessment of Cellular Poly(ADP-ribosyl)ation Capacity

1999 • 15 citations