Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

2005 • 4,715 citations

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

1999 • 2,095 citations

The PARP superfamily

2004 • 1,377 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

2005 • 874 citations

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1998 • 793 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

1999 • 713 citations

Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1

2002 • 674 citations

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

2003 • 606 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

2000 • 572 citations

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

1998 • 550 citations

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

2000 • 527 citations

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

2001 • 515 citations

Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells

1999 • 427 citations

A means to a DNA end: the many roles of Ku

2004 • 371 citations

DNA Ligase IV Is Essential for V(D)J Recombination and DNA Double-Strand Break Repair in Human Precursor Lymphocytes

1998 • 345 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination

2003 • 291 citations

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

2003 • 288 citations

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

1999 • 286 citations

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

2005 • 242 citations

Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges

1980 • 236 citations

Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks

2004 • 232 citations

PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development

2004 • 213 citations

Transient Stability of DNA Ends Allows Nonhomologous End Joining to Precede Homologous Recombination

2002 • 191 citations

Poly(ADP-ribosyl)ated chromatin domains: access granted

2004 • 189 citations

Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2

2004 • 181 citations

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

1997 • 173 citations

Poly(ADP-ribose) Polymerase and Ku Autoantigen Form a Complex and Synergistically Bind to Matrix Attachment Sequences

1999 • 171 citations

PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli

2004 • 167 citations

Genetic Analysis of the DNA-dependent Protein Kinase Reveals an Inhibitory Role of Ku in Late S–G2 Phase DNA Double-strand Break Repair

2001 • 163 citations

PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression

2003 • 157 citations

DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair

2001 • 153 citations

Identification and Biochemical Characterization of a Werner's Syndrome Protein Complex with Ku70/80 and Poly(ADP-ribose) Polymerase-1

2004 • 142 citations

Poly(ADP-ribose) Reactivates Stalled DNA Topoisomerase I and Induces DNA Strand Break Resealing

2004 • 131 citations

Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice

1999 • 126 citations

Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro

1999 • 118 citations

XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage

2006 • 112 citations

Loss of Nonhomologous End Joining Confers Camptothecin Resistance in DT40 Cells

2004 • 96 citations

Early Embryonic Lethality in PARP-1 AtmDouble-Mutant Mice Suggests a Functional Synergy in Cell Proliferation during Development

2001 • 95 citations

Involvement of Vertebrate Polκ in Rad18-independent Postreplication Repair of UV Damage

2002 • 91 citations

Untitled

1999 • 86 citations

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.

2003 • 58 citations

Genetic Interactions between BLM and DNA Ligase IV in Human Cells

2004 • 58 citations

Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis

2003 • 57 citations

Reverse genetic studies of homologous DNA recombination using the chicken B–lymphocyte line, DT40

2001 • 51 citations