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Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.

Data up to Jan 2025

Published1986
Citations283
References26

Total Citations Per Year

Abstract

References (26)

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin

1983 • 585 citations

Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin.

1984 • 442 citations

Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.

1985 • 430 citations

Molecular and Cellular Mechanisms of Leukocyte Chemotaxis

1981 • 415 citations

Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor).

1981 • 390 citations

Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro.

1985 • 380 citations

Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

1983 • 308 citations

Motility and Adhesiveness in Human Neutrophils

1979 • 264 citations

Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion.

1984 • 259 citations

Increase in vascular permeability induced by leukotriene b4 and the role of polymorphonuclear leukocytes

1982 • 238 citations

Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells.

1984 • 221 citations

Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey

1982 • 199 citations

Inhibition of leukotriene C and leukotriene D biosynthesis.

1980 • 171 citations

Adhesion of leukocytes to endothelium: Roles of divalent cations, surface charge, chemotactic agents and substrate

1980 • 157 citations

The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils.

1984 • 155 citations

Leukotriene B4: A highly potent and stereospecific factor stimulating migration of polymorphonuclear leukocytes

1980 • 150 citations

Degranulation, membrane addition, and shape change during chemotactic factor-induced aggregation of human neutrophils.

1982 • 132 citations

Improved high-performance liquid chromatographic method for isolation of platelet-activating factor from other phospholipids

1983 • 99 citations

Leukotriene C promotes prostacyclin synthesis by human endothelial cells.

1983 • 89 citations

Selective desensitization of neutrophils: further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues.

1981 • 64 citations

Esterification of monohydroxyfatty acids into the lipids of a macrophage cell line

1983 • 60 citations

Human endothelial cells modulate granulocyte adherence and chemotaxis.

1985 • 55 citations

Endothelial cell prostacyclin production induced by activated neutrophils.

1985 • 51 citations

Stimulation of human endothelial cell prostacyclin synthesis by select leukotrienes.

1984 • 45 citations

Agonist specific desensitization of leukotriene C4-stimulated PGI2 biosynthesis in human endothelial cells

1983 • 27 citations

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Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize… (1986) – Proceedings of the National Academy of Sciences | Metascience Observatory Explorer