Endothelium‐derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

The Fluorometric Measurement of Deoxyribonucleic Acid in Animal Tissues with Special Reference to the Central Nervous System

1958 • 1,786 citations

Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

1985 • 1,266 citations

Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein.

1984 • 1,249 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

Bioactive Cardiac Substances: Potent Vasorelaxant Activity in Mammalian Atria

1983 • 711 citations

Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.

1977 • 692 citations

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium

1977 • 683 citations

Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues.

1984 • 676 citations

Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.

1978 • 563 citations

Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.

1984 • 495 citations

Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.

1986 • 397 citations

Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor.

1986 • 381 citations

Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle

1986 • 380 citations

Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

1978 • 327 citations

Hormone and neurotransmitter receptors in an established vascular endothelial cell line.

1976 • 257 citations

Release and properties of endothelium‐derived relaxing factor (EDRF) from endothelial cells in culture

1985 • 230 citations

Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips.

1982 • 228 citations

Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells

1997 • 226 citations

The role of endothelium in the control of vascular tone

1985 • 202 citations

Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells

1986 • 197 citations

Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP.

1979 • 187 citations

Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor.

1986 • 167 citations

Endothelium‐dependent relaxation of the pig aorta: relationship to stimulation of ⁸⁶Rb efflux from isolated endothelial cells

1983 • 166 citations

Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin.

1981 • 155 citations

Characteristics of the P2 purinoceptor that mediates prostacyclin production by pig aortic endothelial cells

1987 • 145 citations

Role of Ca2+ and cyclic AMP in the regulation of the production of prostacyclin by the vascular endothelium.

1982 • 140 citations

Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells

1986 • 132 citations

Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation

1985 • 131 citations

Mechanisms of endothelium-dependent vascular smooth muscle relaxation

1985 • 115 citations

Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta

1985 • 90 citations

Autoradiographic analysis of receptors on vascular endothelium

1987 • 79 citations

Stimulation of endothelial prostacyclin production plays no role in endothelium‐dependent relaxation of the pig aorta

1983 • 58 citations

Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: effects on cyclic GMP production.

1986 • 57 citations

Prostacyclin release stimulated by thrombin or bradykinin in porcine endothelial cells cultured from aorta and umbilical vein

1983 • 57 citations

Stimulation of cyclic AMP production by vasoactive agents in cultured bovine aortic and pulmonary artery endothelial cells

1981 • 53 citations

Prostacyclin stimulation of dog arterial cyclic AMP levels

1979 • 48 citations

Induction of prostacyclin biosynthesis is closely associated with increased guanosine 3',5'-cyclic monophosphate accumulation in cultured human endothelium.

1986 • 40 citations

Prostacyclin biosynthesis in vascular endothelium is not inhibited by cyclic AMP. Studies with 3-isobutyl-1-methylxanthine and forskolin

1982 • 36 citations

Stimulation of bovine endothelial cell angiotensin‐I‐converting enzyme activity by cyclic AMP‐related agents

1986 • 31 citations

Increase in acetylcholine concentrations in the brain of ‘old’ rats following treatment with pyrithioxin (Encephabol)

1987 • 24 citations

PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine

1979 • 22 citations

Mechanisms of Vasodilatation

1986 • 22 citations

Atriopeptin II‐induced relaxation of rabbit aorta is potentiated by M&B 22,948 but not blocked by haemoglobin

1986 • 18 citations

Atriopeptin II and nitrovasodilator-mediated shifts in guanosine 3′,5′-cyclic monophosphate in rat thoracic aorta: Evidence for involvement of distinct guanylate cyclase pools

1985 • 14 citations

Loss of receptor‐mediated ⁸⁶Rb efflux from pig aortic endothelial cells in culture

1983 • 8 citations

Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism

1984 • 6 citations