Genotypic and Phenotypic Characterization of Human Immunodeficiency Virus Type 1 Variants Isolated from Patients Treated with the Protease Inhibitor Nelfinavir

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less

1997 • 2,670 citations

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1995 • 984 citations

STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

1993 • 822 citations

Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

1996 • 776 citations

Treatment of Human Immunodeficiency Virus Infection with Saquinavir, Zidovudine, and Zalcitabine

1996 • 758 citations

Antiretroviral Therapy for HIV Infection in 1997

1997 • 732 citations

Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease

1997 • 591 citations

A Short-Term Study of the Safety, Pharmacokinetics, and Efficacy of Ritonavir, an Inhibitor of HIV-1 Protease

1995 • 569 citations

Antiretroviral Therapy for HIV Infection

1998 • 548 citations

Extensive polymorphisms observed in HIV–1 clade B protease gene using high–density oligonucleotide arrays

1996 • 545 citations

A Preliminary Study of Ritonavir, an Inhibitor of HIV-1 Protease, to Treat HIV-1 Infection

1995 • 484 citations

Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

1996 • 411 citations

The Effect of High-Dose Saquinavir on Viral Load and CD4+ T-Cell Counts in HIV-Infected Patients

1996 • 302 citations

Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. The RV-43 Study Group, the AIDS Clinical Trials Group Virology Committee Resistance Working Group

1993 • 296 citations

Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

1995 • 226 citations

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1994 • 217 citations

Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease

1996 • 209 citations

Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

1995 • 190 citations

In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease

1995 • 185 citations

Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors

1995 • 185 citations

Structural Mechanisms of HIV Drug Resistance

1996 • 177 citations

In Vivo Resistance to a Human Immunodeficiency Virus Type 1 Proteinase Inhibitor: Mutations, Kinetics, and Frequencies

1996 • 174 citations

Mutational Anatomy of an HIV-1 Protease Variant Conferring Cross-resistance to Protease Inhibitors in Clinical Trials

1996 • 154 citations

In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects

1996 • 149 citations

A Preliminary Evaluation of Nelfinavir Mesylate, an Inhibitor of Human Immunodeficiency Virus (HIV)‐1 Protease, to Treat HIV Infection

1998 • 148 citations

Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors.

1996 • 117 citations

Human Immunodeficiency Virus Type 1 Protease Inhibitors

1997 • 110 citations

Three-dimensional Structure of a Mutant HIV-1 Protease Displaying Cross-resistance to All Protease Inhibitors in Clinical Trials

1995 • 107 citations

Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538)

1996 • 107 citations

Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro

1997 • 59 citations

Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor

1995 • 55 citations

Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir

1997 • 34 citations

Saquinavir/zidovudine combination in patients with advanced HIV infection and no prior antiretroviral therapy: CD4 + lymphocyte/plasma RNA changes, and emergence of HIV strains with reduced phenotypic sensitivity

1996 • 23 citations

A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A

1997 • 23 citations

Inhibitors of HIV-1 Protease

2018 • 2 citations