Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1995 • 984 citations

STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

1993 • 822 citations

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

1969 • 779 citations

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

1994 • 526 citations

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

1990 • 382 citations

Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity

1989 • 373 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

The HIV-1 Protease as a Therapeutic Target for AIDS

1992 • 343 citations

Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles

1993 • 228 citations

Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

1995 • 226 citations

Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents

1993 • 226 citations

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1994 • 217 citations

Sensitive, soluble chromogenic substrates for HIV-1 proteinase.

1990 • 200 citations

Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

1995 • 190 citations

Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase

1991 • 186 citations

An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

1990 • 186 citations

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease.

1994 • 172 citations

In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.

1993 • 129 citations

Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor

1994 • 94 citations

Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease

1996 • 70 citations

Human immunodeficiency virus type 1 protease inhibitors irreversibly block infectivity of purified virions from chronically infected cells

1992 • 67 citations

Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor

1995 • 55 citations

High-level expression of self-processed HIV-1 protease in Escherichia coli using a synthetic gene

1989 • 47 citations

PCR amplification of HIV-1 proteinase sequences directly from Lab isolates allows determination of five conserved domains

1992 • 34 citations

In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor

1993 • 33 citations

Antiviral properties of aminodiol inhibitors against human immunodeficiency virus and protease

1995 • 13 citations

GENOTYPIC CHARACTERISATION OF HIV-1 FROM PATIENTS AFTER PROLONGED TREATMENT WITH THE PROTEINASE INHIBITOR SAQUINAVIR

1994 • 6 citations

DMP450, a new cyclic urea inhibitor of HIV protease with potent in vitro antiviral activity

1995 • 4 citations