Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 3,000 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

1988 • 1,634 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

1989 • 1,155 citations

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1995 • 984 citations

Rational Design of Peptide-Based HIV Proteinase Inhibitors

1990 • 910 citations

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1989 • 883 citations

STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

1993 • 822 citations

Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

1991 • 686 citations

Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy

1995 • 637 citations

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

1993 • 606 citations

Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

1994 • 584 citations

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

1994 • 526 citations

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.

1991 • 398 citations

Crystal structure of HIV-1 protease in complex with VX-478, a potent and orally bioavailable inhibitor of the enzyme

1995 • 385 citations

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1993 • 372 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

A molecular clone of HTLV-III with biological activity

1985 • 320 citations

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

1993 • 320 citations

Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

1995 • 226 citations

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1994 • 217 citations

Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing

1993 • 200 citations

Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine

1992 • 200 citations

Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

1995 • 190 citations

In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease

1995 • 185 citations

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease.

1994 • 172 citations

Therapy for Human Immunodeficiency Virus Infection

1993 • 164 citations

In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine

1992 • 155 citations

Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro

1993 • 153 citations

A Short-Term Clinical Evaluation of L-697,661, a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase

1993 • 147 citations

Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease

1991 • 133 citations

In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.

1993 • 129 citations

Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance

1994 • 98 citations

Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor

1994 • 94 citations

Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine

1987 • 89 citations

Analysis of resistance to human immunodeficiency virus type 1 protease inhibitors by using matched bacterial expression and proviral infection vectors

1995 • 75 citations

HIV protease inhibitors: their anti-HIV activity and potential role in treatment.

1993 • 67 citations

Didanosine and zidovudine resistance patterns in clinical isolates of human immunodeficiency virus type 1 as determined by a replication endpoint concentration assay

1992 • 46 citations

Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323

1994 • 44 citations

In vitro Resistance to an Inhibitor of HIV Proteinase (Ro 31-8959) Relative to Inhibitors of Reverse Transcriptase (AZT and TIBO)

1993 • 35 citations

Multiple Mutations in the Human Immunodeficiency Virus Protease Gene Are Responsible for Decreased Susceptibility to Protease Inhibitors

1995 • 30 citations

In vitro Selection of Human Immunodeficiency Virus Type 1 Resistant to Ro 31-8959 Proteinase Inhibitor

1993 • 29 citations

GENOTYPIC CHARACTERISATION OF HIV-1 FROM PATIENTS AFTER PROLONGED TREATMENT WITH THE PROTEINASE INHIBITOR SAQUINAVIR

1994 • 6 citations