Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

Data Analysis and Regression.

1979 • 1,739 citations

The jackknife-a review

1974 • 1,426 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1995 • 984 citations

Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

1996 • 776 citations

Linear Models for Unbalanced Data

1989 • 604 citations

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

1995 • 546 citations

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

1994 • 526 citations

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

1994 • 402 citations

Crystal structure of HIV-1 protease in complex with VX-478, a potent and orally bioavailable inhibitor of the enzyme

1995 • 385 citations

An Improved Sequentially Rejective Bonferroni Test Procedure

1987 • 364 citations

The Effect of High-Dose Saquinavir on Viral Load and CD4+ T-Cell Counts in HIV-Infected Patients

1996 • 302 citations

Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

1995 • 226 citations

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1994 • 217 citations

Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

1995 • 190 citations

Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase

1991 • 186 citations

In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease

1995 • 185 citations

Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors

1995 • 185 citations

In Vivo Resistance to a Human Immunodeficiency Virus Type 1 Proteinase Inhibitor: Mutations, Kinetics, and Frequencies

1996 • 174 citations

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease.

1994 • 172 citations

A Short-Term Clinical Evaluation of L-697,661, a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase

1993 • 147 citations

Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors

1993 • 110 citations

Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538)

1996 • 107 citations

Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor

1994 • 94 citations

Resistance of HIV Type 1 to Proteinase Inhibitor Ro 31-8959

1995 • 71 citations

Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor

1995 • 55 citations

SC-52151, a novel inhibitor of the human immunodeficiency virus protease

1995 • 39 citations

In vitro Resistance to an Inhibitor of HIV Proteinase (Ro 31-8959) Relative to Inhibitors of Reverse Transcriptase (AZT and TIBO)

1993 • 35 citations

Multiple Mutations in the Human Immunodeficiency Virus Protease Gene Are Responsible for Decreased Susceptibility to Protease Inhibitors

1995 • 30 citations

In vitro Selection of Human Immunodeficiency Virus Type 1 Resistant to Ro 31-8959 Proteinase Inhibitor

1993 • 29 citations

A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs

1994 • 18 citations

Identification of an amino acid substitution involved in the reduction of sensitivity of HIV-1 to an inhibitor of viral proteinase.

1994 • 16 citations