Extensive polymorphisms observed in HIV–1 clade B protease gene using high–density oligonucleotide arrays

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

1991 • 2,692 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

Light-generated oligonucleotide arrays for rapid DNA sequence analysis.

1994 • 1,353 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1995 • 984 citations

Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes

1993 • 788 citations

Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)

1985 • 718 citations

DNA polymerase fidelity and the polymerase chain reaction.

1991 • 441 citations

Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity

1989 • 373 citations

A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides.

1995 • 348 citations

Using oligonucleotide probe arrays to access genetic diversity

1999 • 345 citations

Crystal structure of a retroviral protease proves relationship to aspartic protease family

1989 • 345 citations

Retroviral protease-like sequence in the yeast transposon Ty 1

1985 • 219 citations

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1994 • 217 citations

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease.

1994 • 172 citations

Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation.

1988 • 127 citations

Use of Self-Sustained Sequence Replication Amplification Reaction to Analyze and Detect Mutations in Zidovudine-Resistant Human Immunodeficiency Virus

1991 • 70 citations

HIV‐1 Protease inhibitors: Their development, mechanism of action and clinical potential

1995 • 28 citations

Advanced DNA sequencing technologies

1994 • 19 citations