Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. The RV-43 Study Group, the AIDS Clinical Trials Group Virology Committee Resistance Working Group

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1984 • 6,841 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons

1989 • 1,090 citations

Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

1991 • 686 citations

Plasma Viremia in Human Immunodeficiency Virus Infection

1989 • 575 citations

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

1992 • 429 citations

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.

1991 • 398 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

Standardization of sensitive human immunodeficiency virus coculture procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. The NIH/NIAID/DAIDS/ACTG Virology Laboratories

1992 • 229 citations

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1990 • 208 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Isolation of drug-resistant variants of HIV-1 from patients on long-term zidovudine therapy

1989 • 181 citations

Rapid and sensitive viral culture method for human immunodeficiency virus type 1

1988 • 137 citations

Two-Drug Combinations of Zidovudine, Didanosine, and Recombinant Interferon- A Inhibit Replication of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Synergistically In Vitro

1991 • 131 citations

HIV-1 sensitivity to zidovudine and clinical outcome in children

1992 • 108 citations

Decreased In Vitro Susceptibility to Zidovudine of HIV Isolates Obtained from Patients with AIDS

1990 • 100 citations

HIV Drug Resistance

1992 • 74 citations

Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization.

1991 • 73 citations

Characterization of HIV Isolates Arising After Prolonged Zidovudine Therapy

1992 • 51 citations

Dynamic changes in HIV‐1 quasispecies from azidothymidine (AZT)‐treated patients

1992 • 42 citations

Susceptibility of HIV-1 isolates to zidovudine: correlation between widely applicable culture test and PCR analysis.

1992 • 41 citations

Susceptibility testing by polymerase chain reaction DNA quantitation: a method to measure drug resistance of human immunodeficiency virus type 1 isolates.

1992 • 33 citations