Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Points of control in inflammation

2002 • 2,599 citations

Pathways of Oxidative Damage

2003 • 2,051 citations

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

2004 • 2,037 citations

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2002 • 1,849 citations

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

2002 • 1,442 citations

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

2000 • 1,411 citations

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

2003 • 1,353 citations

Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

2003 • 1,204 citations

Nrf2 signaling in coordinated activation of antioxidant gene expression

2004 • 1,187 citations

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

2002 • 1,186 citations

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

2003 • 1,140 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

2001 • 1,085 citations

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

2003 • 1,065 citations

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

2004 • 948 citations

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

2003 • 844 citations

Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles

2004 • 821 citations

Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

2003 • 791 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

2003 • 761 citations

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

2003 • 735 citations

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

2001 • 721 citations

Functional antioxidant responsive elements

1997 • 702 citations

Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice

2002 • 652 citations

Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway

2003 • 644 citations

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

2001 • 639 citations

Phytochemicals from Cruciferous Plants Protect against Cancer by Modulating Carcinogen Metabolism

2001 • 608 citations

Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

2003 • 587 citations

Structure of a β-TrCP1-Skp1-β-Catenin Complex

2003 • 577 citations

Nrf2 is essential for protection against acute pulmonary injury in mice

1999 • 572 citations

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

2001 • 568 citations

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

2004 • 504 citations

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3

2003 • 498 citations

Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

2003 • 496 citations

Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium

2003 • 447 citations

Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

2002 • 447 citations

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

2003 • 437 citations

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase

2003 • 415 citations

The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy

2000 • 396 citations

COP9 Signalosome

2003 • 393 citations

The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm

2002 • 340 citations

STRUCTURE OF A BETA-TRCPI-SKP1-BETA-CATENIN COMPLEX: DESTRUCTION MOTIF BINDING AND LYSINE SPECIFICITY OF THE SCF(BETA-TRCP1) UBIQUITIN LIGASE

2003 • 340 citations

Nrf2-deficient female mice develop lupus-like autoimmune nephritis11See Editorial by Byrd and Thomas, p. 1606.

2001 • 339 citations

Oxidative stress and aging: beyond correlation

2002 • 335 citations

BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases

2003 • 330 citations

Role of Oxidative Stress and Antioxidants in Neurodegenerative Diseases

2002 • 325 citations

NF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons

2003 • 303 citations

Accelerated DNA Adduct Formation in the Lung of the Nrf2 Knockout Mouse Exposed to Diesel Exhaust

2001 • 294 citations

DNA and Free Radicals

1993 • 291 citations

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

2001 • 289 citations

SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53

2000 • 271 citations

Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

2001 • 245 citations

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

2003 • 186 citations

Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2

2003 • 166 citations

Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage

2002 • 137 citations

Brain Oxidative Stress in Animal Models of Accelerated Aging and the Age-related Neurodegenerative Disorders, Alzheimers Disease and Huntingtons Disease

2001 • 133 citations

RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex

2004 • 121 citations

Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation

2002 • 76 citations

Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells

2000 • 51 citations

Intermediate filament aggregation in fibroblasts of giant axonal neuropathy patients is aggravated in non dividing cells and by microtubule destabilization

2003 • 49 citations