Nrf2 signaling in coordinated activation of antioxidant gene expression

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2002 • 1,849 citations

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

1994 • 1,512 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

2003 • 1,353 citations

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

1999 • 1,233 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Reactions of oxyl radicals with DNA

1995 • 1,041 citations

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁ gene

1996 • 1,027 citations

Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription

2002 • 984 citations

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

2003 • 844 citations

Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

2003 • 791 citations

Functional antioxidant responsive elements

1997 • 702 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

1996 • 634 citations

GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION

1989 • 624 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

Multiple pathways control protein kinase C phosphorylation

2000 • 598 citations

Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

2003 • 587 citations

Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2

1999 • 584 citations

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

2004 • 561 citations

Iron Homeostasis, Oxidative Stress, and DNA Damage

1997 • 557 citations

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

1998 • 553 citations

Glutathione Transferases and Cancer

1992 • 548 citations

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

2000 • 515 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

1991 • 499 citations

Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

2003 • 496 citations

Free radicals and phagocytic cells

1995 • 487 citations

Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

2003 • 476 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium

2003 • 447 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins

1994 • 434 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Regulation of genes encoding NAD(P)H:quinone oxidoreductases

2000 • 419 citations

Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun.

1994 • 418 citations

Glutathione S-transferases, structure, regulation, and therapeutic implications

1993 • 409 citations

Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells

2000 • 406 citations

The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.

1995 • 393 citations

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage

1990 • 364 citations

Transcriptional Regulation of the Antioxidant Response Element

2000 • 364 citations

Oxidative Stress and Mitochondrial DNA Mutations in Human Aging

1998 • 355 citations

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.

1992 • 353 citations

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

1993 • 344 citations

The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm

2002 • 340 citations

Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism

2000 • 339 citations

Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system

2002 • 334 citations

Physiology of oxygen radicals

1986 • 330 citations

Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE)^,†,‡

2001 • 322 citations

Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

2003 • 314 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress

2003 • 300 citations

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

1999 • 290 citations

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

2001 • 289 citations

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

1998 • 278 citations

Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.

1989 • 272 citations

Redox sensing by prokaryotic transcription factors

2000 • 264 citations

Neutrophil signal transduction and activation of the respiratory burst

1993 • 262 citations

Possible Role of Oxidative Damage in Metal-Induced Carcinogenesis

1995 • 261 citations

Inhibition of ERK and p38 MAP Kinases Inhibits Binding of Nrf2 and Induction of GCS Genes

2000 • 237 citations

Erk Activation Is Required for Nrf2 Nuclear Localization during Pyrrolidine Dithiocarbamate Induction of Glutamate Cysteine Ligase Modulatory Gene Expression in HepG2 Cells

2003 • 232 citations

Mechanisms for Redox Control of Gene Expression

1999 • 231 citations

Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells

2001 • 229 citations

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.

1995 • 210 citations

Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene

2000 • 205 citations

Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens

2001 • 202 citations

Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells

2002 • 193 citations

NAD(P)H:quinone oxidoreductase1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase.

1994 • 193 citations

The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents

1999 • 176 citations

Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family

1993 • 161 citations

Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domain.

1993 • 154 citations

ARE- and TRE-mediated Regulation of Gene Expression

1995 • 140 citations

Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

2002 • 137 citations

hMAF, a Small Human Transcription Factor That Heterodimerizes Specifically with Nrf1 and Nrf2

1997 • 124 citations

酵母での遺伝的選択によるNF-E2関連転写因子、Nrf1のクローニング

1993 • 123 citations

Essential Role of Phosphatidylinositol 3-Kinase-Dependent CCAAT/Enhancer Binding Protein Activation in the Induction of Glutathione S-Transferase by Oltipraz

2003 • 109 citations

Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

1990 • 105 citations

Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice.

1992 • 85 citations

Human MafG Is a Functional Partner for p45 NF-E2 in Activating Globin Gene Expression

1997 • 84 citations

Role of cytochrome P₁ in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants

1987 • 80 citations

An introduction to oxygen free radicals

1996 • 79 citations

Human Antioxidant-Response-Element-Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression. Effect of Sulfhydryl Modifying Agents

1994 • 72 citations

Ozone, NO, and NO2: oxidant air pollutants and more.

1994 • 71 citations

Human Antioxidant-Response-Element-Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression

1994 • 63 citations

Disruption of c-Fos Leads to Increased Expression of NAD(P)H:Quinone Oxidoreductase1 and GlutathioneS-Transferase

1998 • 44 citations

Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein

1999 • 39 citations

Reactive Oxygen Intermediates as Primary Signals and Second Messengers in the Activation of Transcription Factors

1997 • 29 citations

Ozone, NO, and NO 2 : Oxidant Air Pollutants and More

1994 • 25 citations

Glutathione homeostasis in rats chronically treated with ethanol

1992 • 17 citations

Chapter 17 Role of NF-E2 related factors in oxidative stress

2001 • 4 citations