Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway

Free radicals in biology and medicine

1991 • 17,840 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Free radicals in biology and medicine

1985 • 2,999 citations

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2002 • 1,849 citations

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

2002 • 1,186 citations

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

2001 • 1,085 citations

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁ gene

1996 • 1,027 citations

An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen

2001 • 745 citations

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

2001 • 721 citations

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

2001 • 639 citations

Nrf2 is essential for protection against acute pulmonary injury in mice

1999 • 572 citations

Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

2002 • 564 citations

Hsp70 Prevents Activation of Stress Kinases

1997 • 516 citations

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

2001 • 438 citations

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

1990 • 422 citations

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

2000 • 366 citations

The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm

2002 • 340 citations

The Unfolded Protein Response Regulates Multiple Aspects of Secretory and Membrane Protein Biogenesis and Endoplasmic Reticulum Quality Control

2000 • 338 citations

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.

2001 • 327 citations

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

2001 • 323 citations

Chaperones Hsp70 and Hsp40 Suppress Aggregate Formation and Apoptosis in Cultured Neuronal Cells Expressing Truncated Androgen Receptor Protein with Expanded Polyglutamine Tract

2000 • 314 citations

Protective Alterations in Phase 1 and 2 Metabolism of Aflatoxin B1 by Oltipraz in Residents of Qidong, People's Republic of China

1999 • 312 citations

Heat shock proteins: regulators of stress response and apoptosis

1998 • 300 citations

Accelerated DNA Adduct Formation in the Lung of the Nrf2 Knockout Mouse Exposed to Diesel Exhaust

2001 • 294 citations

Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2-Dithiole-3-thione

2001 • 293 citations

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

2001 • 289 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

2001 • 245 citations

Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

1987 • 242 citations

Role of Hsp70 in regulation of stress‐kinase JNK: implications in apoptosis and aging

1998 • 240 citations

Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells

2001 • 229 citations

Chemoprevention by inducers of carcinogen detoxication enzymes.

1997 • 215 citations

Carbonyl reductase

2000 • 199 citations

Protein Folding In Vivo: Unraveling Complex Pathways

1997 • 170 citations

Linkage Analysis of Susceptibility to Hyperoxia

2002 • 169 citations

The Rat Quinone Reductase Antioxidant Response Element

1995 • 153 citations

Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging

2000 • 148 citations

A Randomized Phase IIb Trial of Anethole Dithiolethione in Smokers with Bronchial Dysplasia

2002 • 146 citations

Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithioI-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard

1986 • 144 citations

Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

2002 • 137 citations

Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions

2000 • 106 citations

Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer l,2-dithiole-3-thione

1992 • 98 citations

Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.

1990 • 87 citations

Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.

1993 • 82 citations

Isolation of cDNAs representing dithiolethione-responsive genes

1996 • 79 citations

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of γ-glutamylcysteine synthetase

2002 • 77 citations

DRAGON View: information visualization for annotated microarray data

2002 • 34 citations

UBI4, the polyubiquitin gene of Saccharomyces cerevisiae, is a heat shock gene that is also subject to catabolite derepression control

1997 • 34 citations

Time-dependent changes in ARE-driven gene expression by use of a noise-filtering process for microarray data

2002 • 29 citations

Constitutive and interferon-γ-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 11EMBL accession number for MECL1 cDNA: Y13640.1

1998 • 26 citations

Involvement of Hepatic Aldehyde Oxidase in Conversion of 1-Methyl-4-phenyl-2,3-dihydropyridinium (MPDP+) to 1-Methyl-4-phenyl-5,6-dihydro-2-pyridone

1998 • 20 citations

Kinetic Constraints for the Thiolysis of 4-Methyl-5-(pyrazin-2-yl)-1,2-dithiole-3-thione (Oltipraz) and Related Dithiole-3-thiones in Aqueous Solution

2001 • 17 citations

On the Reduction of Dithiolethiones and Dithiolylium Ions by NADPH and Glutathione Reductase

2000 • 10 citations