The Yeast α2 and Mcm1 Proteins Interact through a Region Similar to a Motif Found in Homeodomain Proteins of Higher Eukaryotes

Homeobox genes and axial patterning

1992 • 2,688 citations

High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis

1989 • 1,357 citations

Transcriptional regulation

1991 • 893 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

1995 • 396 citations

The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein

1994 • 378 citations

A repressor (MATα2 product) and its operator control expression of a set of cell type specific genes in yeast

1985 • 368 citations

The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein

1988 • 348 citations

Structure of serum response factor core bound to DNA

1995 • 340 citations

Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MATα cells

1988 • 323 citations

extradenticle Raises the DNA binding specificity of homeotic selector gene products

1994 • 269 citations

extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1

1993 • 264 citations

Crystal Structure of the MATa1/MATα2 Homeodomain Heterodimer Bound to DNA

1995 • 260 citations

abdA expression in Drosophila embryos.

1990 • 241 citations

A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.

1989 • 239 citations

Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

1990 • 239 citations

Recursive PCR: a novel technique for total gene synthesis

1992 • 234 citations

Cooperative Interactions between HOX and PBX Proteins Mediated by a Conserved Peptide Motif

1995 • 224 citations

a1 Protein alters the dna binding specificity of α2 repressor

1988 • 218 citations

The WD repeats of Tup1 interact with the homeo domain protein alpha 2.

1994 • 207 citations

The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.

1994 • 207 citations

Differential and stage-related expression in embryonic tissues of a new human homoeobox gene

1986 • 182 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer

1992 • 170 citations

Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins.

1994 • 157 citations

Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free.

1988 • 150 citations

Differential DNA sequence recognition is a determinant of specificity in homeotic gene action.

1992 • 146 citations

The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1.

1994 • 145 citations

Binding of yeast al and α2 as a heterodimer to the operator DNA of a haploid-specific gene

1990 • 132 citations

Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 • 125 citations

Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction.

1995 • 122 citations

A short, disordered protein region mediates interactions between the homeodomain of the yeast α2 protein and the MCM1 protein

1993 • 120 citations

Transcriptional repression directed by the yeast α2 protein in vitro

1994 • 118 citations

The human c-fos serum response factor and the yeast factors GRM/PRTF have related DNA-binding specificities.

1988 • 117 citations

Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos.

1992 • 104 citations

Meiotic induction of the yeast HOP1 gene is controlled by positive and negative regulatory sites.

1992 • 82 citations

Yeast a1 and α2 Homeodomain Proteins Form a DNA-binding Activity with Properties Distinct from those of either Protein

1993 • 78 citations

Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster.

1994 • 77 citations

Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites.

1993 • 75 citations

Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos.

1993 • 74 citations

Conserved sequence elements in the 5′ region of the Ultrabithorax transcription unit

1987 • 72 citations

The carboxy-terminal tail of the homeo domain protein alpha 2 is required for function with a second homeo domain protein.

1993 • 68 citations

A homeo domain protein lacking specific side chains of helix 3 can still bind DNA and direct transcriptional repression.

1995 • 63 citations

MCM1 point mutants deficient in expression of alpha-specific genes: residues important for interaction with alpha 1.

1994 • 61 citations

Differential DNA binding properties of three human homeodomain proteins

1992 • 54 citations

37 A Combinatorial Regulatory Circuit in Budding Yeast

1992 • 53 citations

NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.

1992 • 53 citations

Altered DNA Recognition and Bending by Insertions in the α2 Tail of the Yeast a1/α2 Homeodomain Heterodimer

1995 • 48 citations

Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila.

1994 • 46 citations

DNA bending by the a1 and α2 homeodomain proteins from yeast

1995 • 25 citations