Genetic selection for mutations that impair the co‐operative binding of lambda repressor

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli

1983 • 810 citations

The operator-binding domain of λ repressor: structure and DNA recognition

1982 • 528 citations

Autodigestion of lexA and phage lambda repressors.

1984 • 505 citations

Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions

1988 • 500 citations

Cooperative binding of λ repressors to sites separated by integral turns of the DNA helix

1986 • 450 citations

A pSC101-derived plasmid which shows no sequence homology to other commonly used cloning vectors

1984 • 447 citations

Interactions between DNA-bound repressors govern regulation by the λ phage repressor

1979 • 329 citations

Repressor structure and the mechanism of positive control

1983 • 324 citations

Refined 1.8 Å crystal structure of the λ repressor-operator complex

1992 • 299 citations

A mutant Escherichia coli σ70 subunit of RNA polymerase with altered promoter specificity

1989 • 297 citations

Cloning vectors that yield high levels of single-stranded DNA for rapid DNA sequencing

1984 • 238 citations

The lambda repressor contains two domains.

1979 • 238 citations

Lysine-156 and serine-119 are required for LexA repressor cleavage: a possible mechanism.

1987 • 228 citations

MULTIPARTITE GENETIC CONTROL ELEMENTS: COMMUNICATION BY DNA LOOP

1989 • 188 citations

EcoRI analysis of bacteriophage P22 DNA packaging

1978 • 146 citations

The λ phage att site: functional limits and interaction with Int protein

1980 • 146 citations

Sequence determinants of promoter activity

1982 • 145 citations

Patterns of λ int recognition in the regions of strand exchange

1983 • 143 citations

Regulatory functions of the λ repressor reside in the amino-terminal domain

1979 • 143 citations

Mutations in lambda repressor's amino-terminal domain: implications for protein stability and DNA binding.

1983 • 139 citations

Changing the DNA-binding specificity of a repressor

1983 • 119 citations

Genetics of bacteriophage P22

1972 • 117 citations

Position and density effects on repression by stationary and mobile DNA-binding proteins.

1989 • 115 citations

Bacteriophage lambda int protein recognizes two classes of sequence in the phage att site: characterization of arm-type sites.

1982 • 113 citations

Structure and Function of the Phage att Site: Size, Int-binding Sites, and Location of the Crossover Point

1981 • 107 citations

DNA looping.

1992 • 99 citations

Intramolecular cleavage of lexA and phage .lambda. repressors: dependence of kinetics on repressor concentration, pH, temperature, and solvent

1986 • 98 citations

Interaction of int protein with specific sites on λ att DNA

1979 • 98 citations

Mutant lambda phage repressor with a specific defect in its positive control function.

1982 • 93 citations

Superinfection exclusion by P22 prophage in lysogens of Salmonella typhimurium

1971 • 91 citations

Control of gal transcription through DNA looping: inhibition of the initial transcribing complex.

1992 • 89 citations

DNA looping in cellular repression of transcription of the galactose operon.

1990 • 86 citations

Structural and regulatory divergence among site-specific recombination genes of lambdoid phage

1986 • 76 citations

Interaction at a distance between λrepressers disrupts gene activation

1988 • 73 citations

The isolation and characterization of mutants of the integration host factor (IHF) of Escherichia coli with altered, expanded DNA-binding specificities.

1992 • 67 citations

Interaction of spatially separated protein-DNA complexes for control of gene expression: operator conversions.

1988 • 67 citations

λ Repressor: A Model System for Understanding Protein–DNA Interactions and Protein Stability

1990 • 65 citations

A new gene of bacteriophage P22 which regulates synthesis of antirepressor

1980 • 65 citations

GENERAL SELECTION FOR SPECIFIC DNA-BINDING ACTIVITIES

1986 • 61 citations

Inducible reactivation and mutagenesis of UV-irradiated bacteriophage P22 in Salmonella typhimurium LT2 containing the plasmid pKM101

1978 • 60 citations

Mutations Defining the Operator-binding Sites of Bacteriophage Repressor

1983 • 50 citations

MUTATIONS THAT IMPROVE THE ANT PROMOTER OF SALMONELLA PHAGE P22

1985 • 45 citations

Transfer of chimeric plasmids among Salmonella typhimurium strains by P22 transduction.

1982 • 41 citations

A genetic analysis of Xis and FIS interactions with their binding sites in bacteriophage lambda

1991 • 40 citations

Probing the structure of gal operator-repressor complexes. Conformation change in DNA.

1987 • 38 citations

DNA sequence determinants of lambda repressor binding in vivo.

1988 • 34 citations

An early regulatory gene of Salmonella phage P22 analogous to gene N of coliphage λ

1975 • 33 citations

An operator-induced conformational change in the C-terminal domain of the lambda repressor.

1992 • 32 citations

Bacteriophage P22 proteins specified by the region between genes 9 and erf

1980 • 31 citations

Mutations that improve the binding of yeast FLP recombinase to its substrate.

1988 • 21 citations

Phage lambda Cro protein and cI repressor use two different patterns of specific protein-DNA interactions to achieve sequence specificity in vivo.

1989 • 20 citations

P22 repressor mutants deficient in co-operative binding and DNA loop formation.

1989 • 15 citations

Mutant lambda repressors with increased operator affinities reveal new, specific protein-DNA contacts.

1992 • 13 citations