Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase.

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Microtubule assembly nucleated by isolated centrosomes

1984 • 775 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Monoclonal antibodies to mitotic cells.

1983 • 609 citations

γ-Tubulin is a highly conserved component of the centrosome

1991 • 566 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA

1987 • 550 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

1990 • 444 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation

1977 • 416 citations

Induction of nuclear envelope breakdown, chromosome condensation, and spindle formation in cell-free extracts.

1985 • 407 citations

γ-Tubulin is present in Drosophila melanogaster and homo sapiens and is associated with the centrosome

1991 • 405 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

1989 • 376 citations

Centrioles in the cell cycle. I. Epithelial cells.

1982 • 362 citations

Fate of microtubule-organizing centers during myogenesis in vitro.

1985 • 331 citations

The fission yeast γ-tubulin is essential for mitosis and is localized at microtubule organizing centers

1991 • 294 citations

Structural and chemical characterization of isolated centrosomes

1987 • 292 citations

Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy.

1981 • 271 citations

The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition.

1990 • 262 citations

Phosphoproteins are components of mitotic microtubule organizing centers.

1984 • 246 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

Centrosomes and mitotic poles

1984 • 229 citations

Control of microtubule nucleation and stability in Madin-Darby canine kidney cells: the occurrence of noncentrosomal, stable detyrosinated microtubules.

1987 • 199 citations

Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle.

1981 • 191 citations

Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle.

1990 • 176 citations

Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2

1989 • 167 citations

Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro

1980 • 155 citations

Identification of microtubule-associated proteins in the centrosome, spindle, and kinetochore of the early Drosophila embryo.

1989 • 151 citations

The mitotic apparatus-associated 51-kDa protein from sea urchin eggs is a GTP-binding protein and is immunologically related to yeast polypeptide elongation factor 1 alpha.

1990 • 134 citations

6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity

1988 • 133 citations

Identification and localization of a novel, cytoskeletal, centrosome-associated protein in PtK2 cells.

1988 • 129 citations

A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity.

1989 • 126 citations

Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes.

1984 • 121 citations

6-Dimethylaminopurine (6-DMAP), a reversible inhibitor of the transition to metaphase during the first meiotic cell division of the mouse oocyte

1989 • 113 citations

Calcium‐modulated contractile proteins associated with the eucaryotic centrosome

1986 • 108 citations

Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitope

1990 • 108 citations

Regulation of microtubule dynamics and nucleation during polarization in MDCK II cells.

1990 • 107 citations

Cytoskeletal control of centrioles movement during the establishment of polarity in Madin-Darby canine kidney cells.

1990 • 105 citations

Parthenogenesis in Xenopus eggs requires centrosomal integrity.

1990 • 103 citations

Microtubule polarities indicate that nucleation and capture of microtubules occurs at cell surfaces in Drosophila.

1989 • 99 citations

Effects of brain microtubule‐associated proteins on microtubule dynamics and the nucleating activity of centrosomes

1990 • 96 citations

p34^cdc2 Kinase is localized to distinct domains within the mitotic apparatus

1990 • 91 citations

A human centrosomal protein is immunologically related to basal body-associated proteins from lower eucaryotes and is involved in the nucleation of microtubules.

1991 • 81 citations

Identification of a minus end-specific microtubule-associated protein located at the mitotic poles in cultured mammalian cells.

1991 • 79 citations

The predicted amino acid sequence of a centrosphere protein in dividing sea urchin eggs is similar to elongation factor (EF-1a)

1990 • 78 citations

Identification of centrosomal proteins in a human lymphoblastic cell line.

1986 • 77 citations

Evidence for microtubule nucleation at plasma membrane-associated sites in Drosophila

1987 • 73 citations

Spatial organization of microtubule-organizing centers and microtubules.

1984 • 69 citations

The mitotic spindle of chinese hamster ovary cells isolated in taxol-containing medium

1984 • 58 citations

Mitotic spindle morphogenesis in animal cells.

1991 • 57 citations

225‐Kilodalton phosphoprotein associated with mitotic centrosomes in sea urchin eggs

1989 • 52 citations

Activity and stability of centrosomes in chinese hamster ovary cells in nucleation of microtubules in vitro

1984 • 52 citations

A novel mitotic spindle pole component that originates from the cytoplasm during prophase.

1986 • 46 citations

Parthenogenesis in Xenopus eggs injected with centrosomes from synchronized human lymphoid cells

1989 • 45 citations

An investigation of the centriole cycle using 3t3 and cho cells

1985 • 42 citations

Murine cDNAs coding for the centrosomal antigen centrosomin A*

1991 • 31 citations

The centriolar complex isolated from starfish spermatozoa

1981 • 31 citations

Meiosis reinitiation as a model system for the study of cell division and cell differentiation.

1990 • 21 citations

Regulation of Protein Kinases Associated with Cyclin A and Cyclin B and Their Effect on Microtubule Dynamics and Nucleation in Xenopus Egg Extracts

1991 • 16 citations

Supracellular Microtubule Alignments In Cell Layers Associated With The Secretion Of Certain Fish Scales

1986 • 11 citations