Genetic Requirements for PIE-1 Localization and Inhibition of Gene Expression in the Embryonic Germ Lineage ofCaenorhabditis elegans

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Identification of genes required for cytoplasmic localization in early C. elegans embryos

1988 • 841 citations

Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.

1987 • 727 citations

Regulation of zygotic gene expression in Drosophila primordial germ cells

1998 • 643 citations

Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos

1983 • 534 citations

Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential

1995 • 451 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans.

1982 • 392 citations

skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

1992 • 387 citations

Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans

1994 • 340 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster

1997 • 318 citations

pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos

1995 • 314 citations

Translational regulation of nanos by RNA localization

1994 • 307 citations

Autoradiographic study of protein and RNA formation during early development of Drosophila eggs

1976 • 290 citations

GLD-1, a Cytoplasmic Protein Essential for Oocyte Differentiation, Shows Stage- and Sex-Specific Expression duringCaenorhabditis elegansGermline Development

1996 • 277 citations

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos

1996 • 260 citations

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos

1996 • 254 citations

The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos

1993 • 251 citations

Splicing Factors Associate with Hyperphosphorylated RNA Polymerase II in the Absence of Pre-mRNA

1997 • 245 citations

Translational control of oskar generates Short OSK, the isoform that induces pole plasm assembly

1995 • 243 citations

Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans

1996 • 241 citations

The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos

1992 • 240 citations

Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo

1994 • 231 citations

The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo

1994 • 227 citations

Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II

1998 • 225 citations

Spatial and Temporal Controls Target pal-1 Blastomere-Specification Activity to a Single Blastomere Lineage in C. elegans Embryos

1996 • 219 citations

Localization of oskar RNA regulates oskar translation and requires Oskar protein

1995 • 208 citations

Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity

1997 • 197 citations

Temperature-sensitive developmental mutants of Caenorhabditis elegans

1976 • 170 citations

Parental effects and phenotypic characterization of mutations that affect early development in Caenorhabditis elegans

1980 • 159 citations

Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle

1990 • 158 citations

Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisation

1996 • 156 citations

The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule component

1997 • 142 citations

Increase in nuclear poly(A)-containing RNA at syncytial blastoderm in Drosophila melanogaster embryos

1976 • 114 citations

Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo

1994 • 110 citations

Genetics and mode of expression of temperature-sensitive mutations arresting embryonic development in Caenorhabditis elegans

1980 • 81 citations

Cleavage of RNA Hairpins Mediated by a Developmentally Regulated CCCH Zinc Finger Protein

1996 • 74 citations

Genetic analysis of temperature-sensitive embryogenesis mutants in Caenorhabditis elegans

1981 • 72 citations

The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos

1997 • 67 citations

An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell

1996 • 66 citations

Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans

1995 • 61 citations

Cytostellin: A novel, highly conserved protein that undergoes continuous redistribution during the cell cycle

1992 • 57 citations

Maternal effects and temperature-sensitive period of mutations affecting embryogenesis in Caenorhabditis elegans

1983 • 33 citations

Genes Required for GLP-1 Asymmetry in the EarlyCaenorhabditis elegansEmbryo

1997 • 31 citations

Asymmetric movements of cytoplasmic components in Caenorhabditis elegans zygotes

1986 • 30 citations

Accumulation and Spatial Distribution of Poly(A)⁺RNA in Oocytes and Early Embryos of Drosophila melanogaster

1988 • 21 citations