Diabetes and Vascular Disease

Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

1993 • 28,274 citations

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

1998 • 19,638 citations

Global Prevalence of Diabetes

2004 • 15,420 citations

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

2002 • 10,002 citations

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.

1998 • 8,603 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

1999 • 8,588 citations

Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis

1991 • 8,040 citations

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

1998 • 7,971 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction

1998 • 7,057 citations

Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

2002 • 6,825 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)

1996 • 6,350 citations

Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation

2001 • 6,336 citations

Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001

2003 • 5,872 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

1998 • 5,793 citations

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

2002 • 5,558 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 5,471 citations

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

1998 • 4,813 citations

Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction

2003 • 4,640 citations

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

1991 • 4,548 citations

Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes

2003 • 4,328 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Diabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention Trial

1993 • 4,132 citations

Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial

2004 • 3,776 citations

Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol

1999 • 3,464 citations

MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis

1991 • 3,163 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure

2004 • 2,991 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

2000 • 2,991 citations

MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial

2003 • 2,931 citations

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

1996 • 2,812 citations

The Continuing Epidemics of Obesity and Diabetes in the United States

2001 • 2,803 citations

Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

1988 • 2,740 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Diabetes and Atherosclerosis

2002 • 2,588 citations

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

2004 • 2,571 citations

The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes

2001 • 2,520 citations

Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both

2003 • 2,402 citations

Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)

2003 • 2,138 citations

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators.

2000 • 2,085 citations

The Rising Global Burden of Diabetes and its Complications: Estimates and Projections to the Year 2010

1997 • 1,777 citations

The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years.

1999 • 1,681 citations

Cholesterol Lowering With Simvastatin Improves Prognosis of Diabetic Patients With Coronary Heart Disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)

1997 • 1,657 citations

Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Consensus (TASC).

2000 • 1,642 citations

Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension in Patients With Impaired Glucose Tolerance

2003 • 1,628 citations

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 1,592 citations

ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery—executive summary

2002 • 1,578 citations

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

2000 • 1,537 citations

Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39

1998 • 1,435 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

1999 • 1,300 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

2001 • 1,192 citations

Endothelial dysfunction in diabetes

2000 • 1,146 citations

The way I see it: House officers need formal career development

2002 • 1,137 citations

Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study

2002 • 1,115 citations

ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins

2002 • 1,114 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomised placebo-controlled trial

2002 • 1,028 citations

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

1996 • 1,024 citations

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

2001 • 1,017 citations

Cardiovascular Events and Their Reduction With Pravastatin in Diabetic and Glucose-Intolerant Myocardial Infarction Survivors With Average Cholesterol Levels

1998 • 1,000 citations

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

2002 • 970 citations

MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. European Carotid Surgery Trialists' Collaborative Group.

1991 • 964 citations

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

1990 • 938 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70–99%) or mild (0–29%) carotid stenosis

1992 • 892 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

2001 • 858 citations

High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study

2003 • 791 citations

Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo

1998 • 790 citations

Activation of Receptor for Advanced Glycation End Products

1999 • 775 citations

Update on Some Epidemiologic Features of Intermittent Claudication: The Framingham Study

1985 • 769 citations

The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium

1987 • 765 citations

High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells

1997 • 765 citations

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation.

1997 • 756 citations

Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction

2000 • 754 citations

Peripheral Arterial Disease in Diabetic and Nondiabetic Patients

2001 • 737 citations

Roles for Insulin Receptor, PI3-Kinase, and Akt in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

2000 • 736 citations

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

1996 • 735 citations

NF-κB: pivotal mediator or innocent bystander in atherogenesis?

2001 • 729 citations

Peripheral Arterial Disease in the Elderly

1998 • 728 citations

Intermittent High Glucose Enhances Apoptosis Related to Oxidative Stress in Human Umbilical Vein Endothelial Cells

2003 • 725 citations

Endothelial Regulation of Vasomotion in ApoE-Deficient Mice

2001 • 719 citations

Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus

2002 • 674 citations

Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort

2001 • 671 citations

Impact of Diabetes on Mortality After the First Myocardial Infarction

1998 • 662 citations

Platelet Dysfunction in Type 2 Diabetes

2001 • 643 citations

Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.

1994 • 632 citations

Changing concepts of atherogenesis

2000 • 625 citations

Influence of Diabetes on 5-Year Mortality and Morbidity in a Randomized Trial Comparing CABG and PTCA in Patients With Multivessel Disease

1997 • 623 citations

Regulation of Endothelial Constitutive Nitric Oxide Synthase Gene Expression in Endothelial Cells and In Vivo

2000 • 623 citations

The prevalence of abnormal glucose regulation in patients with coronary artery disease across EuropeThe Euro Heart Survey on diabetes and the heart

2004 • 622 citations

Efficacy, Safety, and Tolerability of Once-Daily Niacin for the Treatment of Dyslipidemia Associated With Type 2 Diabetes<subtitle>Results of the Assessment of Diabetes Control and Evaluation of the Efficacy of Niaspan Trial</subtitle>

2002 • 558 citations

Influence of Diabetes Mellitus on Early and Late Outcome After Percutaneous Transluminal Coronary Angioplasty

1995 • 547 citations

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

2002 • 545 citations

The Impact of Diabetes Mellitus on Mortality From All Causes and Coronary Heart Disease in Women

2001 • 538 citations

Macrophages in Human Atheroma Contain PPARγ

1998 • 536 citations

Effect of Diagnostic Criteria on the Prevalence of Peripheral Arterial Disease

1995 • 524 citations

Effect of Niacin on Lipid and Lipoprotein Levels and Glycemic Control in Patients With Diabetes and Peripheral Arterial Disease

2000 • 519 citations

Contributions of polyol pathway to oxidative stress in diabetic cataract

1999 • 517 citations

Improved endothelial function with metformin in type 2 diabetes mellitus

2001 • 512 citations

Randomised placebo-controlled trial of lisinopril in normotensive patients with insulin-dependent diabetes and normoalbuminuria or microalbuminuria

1997 • 510 citations

Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease

2003 • 494 citations

Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.

1994 • 486 citations

Effects of Diabetes and Level of Glycemia on All-Cause and Cardiovascular Mortality: The San Antonio Heart Study

1998 • 484 citations

Nitric Oxide Modulates the Expression of Monocyte Chemoattractant Protein 1 in Cultured Human Endothelial Cells

1995 • 475 citations

Aspirin Effects on Mortality and Morbidity in Patients With Diabetes Mellitus

1992 • 475 citations

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

1999 • 474 citations

Diabetes Mellitus Enhances Vascular Matrix Metalloproteinase Activity

2001 • 466 citations

Coronary Angioplasty in Diabetic Patients

1996 • 454 citations

High-Density Lipoprotein Restores Endothelial Function in Hypercholesterolemic Men

2002 • 448 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Platelet Glycoprotein IIb/IIIa Inhibitors Reduce Mortality in Diabetic Patients With Non–ST-Segment-Elevation Acute Coronary Syndromes

2001 • 437 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

High Glucose Causes Upregulation of Cyclooxygenase-2 and Alters Prostanoid Profile in Human Endothelial Cells

2003 • 421 citations

Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels

1996 • 416 citations

Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus

2002 • 413 citations

Nitric Oxide Reversibly Inhibits the Migration of Cultured Vascular Smooth Muscle Cells

1996 • 412 citations

Cross-talk between the insulin and angiotensin signaling systems.

1996 • 410 citations

Ascorbate Prevents the Interaction of Superoxide and Nitric Oxide Only at Very High Physiological Concentrations

1998 • 401 citations

Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes

2002 • 387 citations

Endothelial function and coronary artery disease

2001 • 381 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Presidential address: A team for the 21st century: The vascular center

2000 • 373 citations

Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.

1999 • 360 citations

Effects of Pioglitazone on Adipose Tissue Remodeling Within the Setting of Obesity and Insulin Resistance

2001 • 347 citations

Clinical and Economic Impact of Diabetes Mellitus on Percutaneous and Surgical Treatment of Multivessel Coronary Disease Patients

2001 • 342 citations

Hypertriglyceridemic HyperapoB: The Unappreciated Atherogenic Dyslipoproteinemia in Type 2 Diabetes Mellitus

2001 • 341 citations

The role of oxidative stress and NF‐κB activation in late diabetic complications

1999 • 341 citations

Long-Term Risk of First Recurrent Stroke in the Perth Community Stroke Study

1998 • 332 citations

Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells

2002 • 328 citations

Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans

2001 • 321 citations

Differential Regulation of Glucose Transport and Transporters by Glucose in Vascular Endothelial and Smooth Muscle Cells

1993 • 321 citations

Diabetes Mellitus as a Risk Factor for Death From Stroke

1996 • 316 citations

Secondary Prevention of Cardiovascular Events With Long-Term Pravastatin in Patients With Diabetes or Impaired Fasting Glucose

2003 • 313 citations

Endothelium-derived nitric oxide and vascular physiology and pathology

1999 • 308 citations

Advanced Glycation End Products and Endothelial Dysfunction in Type 2 Diabetes

2002 • 307 citations

Insulin Stimulates Both Endothelin and Nitric Oxide Activity in the Human Forearm

1999 • 298 citations

Atherosclerosis and the Two Faces of Endothelial Nitric Oxide Synthase

1998 • 298 citations

Optimizing the Percutaneous Interventional Outcomes for Patients With Diabetes Mellitus

1999 • 294 citations

Anti-Inflammatory and Profibrinolytic Effect of Insulin in Acute ST-Segment–Elevation Myocardial Infarction

2004 • 278 citations

Inhibition of Protein Kinase Cβ Prevents Impaired Endothelium-Dependent Vasodilation Caused by Hyperglycemia in Humans

2002 • 274 citations

Restenosis Rates in Diabetic Patients

1997 • 272 citations

Increased Activity of Endogenous Endothelin in Patients With Type II Diabetes Mellitus

2002 • 261 citations

Temporal changes in prevalence of diabetes and impaired glucose tolerance associated with lifestyle transition occurring in the rural population in India

2004 • 260 citations

β-Blockers and Sudden Cardiac Death

1995 • 257 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Patients With Insulin-Dependent Diabetes Mellitus

1998 • 254 citations

Free Fatty Acids, Insulin Resistance, and Type 2 Diabetes Mellitus

1999 • 241 citations

Effect of the ACE Inhibitor Lisinopril on Mortality in Diabetic Patients With Acute Myocardial Infarction

1997 • 238 citations

Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

1991 • 226 citations

Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.

1997 • 220 citations

Non-insulin-dependent diabetes and its metabolic control are important predictors of stroke in elderly subjects.

1994 • 215 citations

Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis

2001 • 210 citations

Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

1996 • 196 citations

Very Low-Density Lipoprotein Activates Nuclear Factor-κB in Endothelial Cells

1999 • 195 citations

Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo.

1995 • 191 citations

Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues

1994 • 186 citations

Hyperglycemia-Induced Thrombin Formation in Diabetes: The Possible Role of Oxidative Stress

1995 • 184 citations

Significance of chemokines and activated platelets in patients with diabetes

2000 • 182 citations

Endothelin: emerging role in diabetic vascular complications

1999 • 177 citations

The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus

2000 • 176 citations

Predictors of Long-term Patency after Femoropopliteal Angioplasty: Results from the STAR Registry

2001 • 174 citations

Effects of high-density lipoprotein on acetylcholine-induced coronary vasoreactivity

1991 • 174 citations

PPARα Activators Inhibit Tissue Factor Expression and Activity in Human Monocytes

2001 • 170 citations

Platelet hyperactivity and abnormal Ca²⁺homeostasis in diabetes mellitus

2001 • 169 citations

Atherosclerosis and diabetes: The rage connection

2000 • 164 citations

Natural history of claudication: Long-term serial follow-up study of 1244 claudicants

2001 • 157 citations

Mechanism of action of niacin on lipoprotein metabolism

2000 • 154 citations

Endothelium-Dependent Relaxation in Aorta of BB Rat

1987 • 151 citations

Plasminogen Activator Inhibitor Type 1 Is Increased in the Arterial Wall of Type II Diabetic Subjects

2001 • 150 citations

Hypertriglyceridemia and Hyperinsulinemia Are Potent Inducers of Endothelin-1 Release in Humans

1996 • 148 citations

Activation of Tissue Factor–Induced Coagulation and Endothelial Cell Dysfunction in Non–Insulin-Dependent Diabetic Patients With Microalbuminuria

1995 • 147 citations

Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro

2001 • 147 citations

Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles

1993 • 144 citations

[Coronary angioplasty in diabetic patients].

2002 • 133 citations

Traditional Risk Factors and Ischemic Stroke in Young Adults: The Baltimore-Washington Cooperative Young Stroke Study

1996 • 125 citations

Diabetes Induces p66^shcGene Expression in Human Peripheral Blood Mononuclear Cells: Relationship to Oxidative Stress

2005 • 125 citations

Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in NIDDM

1995 • 125 citations

Epidemiology of some peripheral arterial findings in diabetic men and women: Experiences from the Framingham study

1990 • 125 citations

Effect of Diabetes and Associated Conditions on Long-Term Survival After Coronary Artery Bypass Graft Surgery

2004 • 122 citations

Antihypertensive therapy in type 2 diabetes: implications of the appropriate blood pressure control in diabetes (ABCD) trial

1998 • 120 citations

Hyperinsulinemia Enhances Transcriptional Activity of Nuclear Factor-κB Induced by Angiotensin II, Hyperglycemia, and Advanced Glycosylation End Products in Vascular Smooth Muscle Cells

2000 • 119 citations

IMPAIRED ENDOTHELIUMDEPENDENT VASODILATION IN PATIENTS WITH INSULINDEPENDENT DIABETES MELLITUS

1993 • 119 citations

Low Density Lipoprotein

1978 • 117 citations

High-glucose-induced nuclear factor κB activation in vascular smooth muscle cells

2000 • 111 citations

Trends in the Mortality Burden Associated With Diabetes Mellitus

2003 • 110 citations

Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study

1999 • 107 citations

Selective Inhibition of Protein Kinase Cβ ₂ Prevents Acute Effects of High Glucose on Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells

2004 • 106 citations

Uniformity of captopril benefit in the SAVE study: subgroup analysis

1994 • 103 citations

Beta-blocker therapy for secondary prevention of myocardial infarction in elderly diabetic patients

1999 • 101 citations

Insulin modulates circulating endothelin-1 levels in humans

1993 • 93 citations

Impact of Different Platelet Glycoprotein IIb/IIIa Receptor Inhibitors Among Diabetic Patients Undergoing Percutaneous Coronary Intervention

2002 • 92 citations

Perioperative cardiovascular risk stratification of patients with diabetes who undergo elective major vascular surgery

2002 • 89 citations

Not Acute but Chronic Hypertriglyceridemia Is Associated With Impaired Endothelium-Dependent Vasodilation

2000 • 88 citations

Peroxisome proliferator-activated receptors in vascular biology and atherosclerosis: Emerging insights for evolving paradigms

2000 • 86 citations

Impaired Vasoconstriction to Endothelin 1 in Patients With NIDDM

1996 • 85 citations

Five-Year Results of Iliac and Femoropopliteal Angioplasty in Diabetic Patients

1990 • 83 citations

Immunohistochemical and Morphometric Evaluations of Coronary Atherosclerotic Plaques Associated with Myocardial Infarction and Diabetes Mellitus

1998 • 81 citations

Endothelial dysfunction in a model of hyperglycemia and hyperinsulinemia

1995 • 81 citations

FFA-Induced Endothelial Dysfunction Can Be Corrected by Vitamin C

2002 • 79 citations

The lipoprotein lipase activator, NO-1886, suppresses fat accumulation and insulin resistance in rats fed a high-fat diet

2000 • 78 citations

The Role of Hyperglycaemia and Hyperinsulinaemia in Causing Vascular Dysfunction in Diabetes

1996 • 77 citations

Proinflammatory effects of angiotensin II and endothelin: targets for progression of cardiovascular and renal diseases

2002 • 73 citations

Troglitazone Improves Endothelial Dysfunction in Patients with Insulin Resistance

2000 • 63 citations

Predictors of Death and Vascular Events in the Elderly

2000 • 63 citations

Oxidation of low-density lipoprotein in NIDDM: its relationship to fatty acid composition

1995 • 60 citations

Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans

1990 • 59 citations

Differential Secretion of Atrial and Brain Natriuretic Peptide in Critically Ill Patients

2001 • 58 citations

Outcome and cost analysis after femorocrural and femoropedal grafting for critical limb ischaemia

1997 • 56 citations

Diabetes mellitus in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry

2000 • 51 citations

The Influence of Type 2 Diabetes Mellitus in Patients Undergoing Coronary Artery Bypass Graft Surgery

2004 • 51 citations

Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow

2000 • 51 citations

Peripheral Autonomic Impairment in Patients Newly Diagnosed With Type II Diabetes

1994 • 47 citations

Angiotensin-converting enzyme inhibition after myocardial infarction: the trandolapril cardiac evaluation study

1996 • 42 citations

Is diabetes mellitus a risk factor for carotid endarterectomy? A prospective study

2001 • 42 citations

Rate and mode of death during five years of follow-up among patients with acute chest pain with and without a history of diabetes mellitus

1998 • 40 citations

Carotid endarterectomy in diabetic patients

2001 • 40 citations

Thrombomodulin Deficiency in Human Diabetic Nerve Microvasculature

2002 • 34 citations

Impact of Diabetes-Associated Lipoproteins on Generation of Fibrinolytic Regulators from Vascular Endothelial Cells

2002 • 32 citations

Diabetic versus nondiabetic limb-threatening ischemia: outcome of percutaneous iliac intervention.

1999 • 30 citations

In-hospital Outcome for Diabetic Patients with Acute Myocardial Infarction in the Thrombolytic Era

1999 • 29 citations

The Effect of Diabetes Mellitus on the Outcome of Angioplasty for Lower Limb Ischaemia

1992 • 18 citations

Endovascular surgery for chronic limb ischaemia. Factors predicting immediate outcome on the basis of a nationwide vascular registry.

2001 • 14 citations

Deleted Work

1955 • 0 citations