High Glucose Causes Upregulation of Cyclooxygenase-2 and Alters Prostanoid Profile in Human Endothelial Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

2001 • 1,192 citations

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

2002 • 970 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

2001 • 858 citations

Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells

1998 • 797 citations

High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells

1997 • 765 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

2001 • 609 citations

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

2000 • 596 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Prostaglandin endoperoxide synthase: why two isoforms?

1996 • 464 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Superoxide anion is an endothelium-derived contracting factor

1989 • 398 citations

Free radicals in diabetic endothelial cell dysfunction

1994 • 398 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

1989 • 374 citations

Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.

1998 • 350 citations

Tyrosine Nitration as a Mechanism of Selective Inactivation of Prostacyclin Synthase by Peroxynitrite

1997 • 287 citations

Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

1997 • 282 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Patients With Insulin-Dependent Diabetes Mellitus

1998 • 254 citations

Endothelial dysfunction in diabetes mellitus.

1998 • 225 citations

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1998 • 194 citations

Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes

2001 • 185 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells.

1994 • 130 citations

Hypoxia–Reoxygenation Triggers Coronary Vasospasm in Isolated Bovine Coronary Arteries via Tyrosine Nitration of Prostacyclin Synthase

1999 • 79 citations

Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C

1995 • 61 citations