Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

1979 • 4,730 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Interleukin-10

1993 • 1,820 citations

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 • 1,338 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Immune interferon: a pleiotropic lymphokine with multiple effects

1985 • 676 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Lymphokines

1987 • 459 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Interleukin 6 is involved in interleukin 1‐induced activities

1988 • 422 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

1994 • 363 citations

Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes

1990 • 356 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

1992 • 243 citations

Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells

1991 • 236 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

The significance of the concordance rate for Type 1 (insulin-dependent) diabetes in identical twins

1988 • 220 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Regulation of the immune response in lymphatic filariasis and onchocerciasis

1991 • 138 citations

Acquired Defect in Interleukin-2 Production in Patients with Type I Diabetes Mellitus

1986 • 129 citations

Distinct Macrophage Subpopulations in Pancreas of Prediabetic BB/E Rats: Possible Role for Macrophages in Pathogenesis of IDDM

1988 • 116 citations

Studies on the Mechanisms Causing Inhibition of Insulin Secretion in Rat Pancreatic Islets Exposed to Human Interleukin-1β Indicate a Perturbation in the Mitochondrial Function*

1989 • 101 citations

Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes.

1990 • 94 citations

Antibodies to GAD and Tryptic Fragments of Islet 64K Antigen as Distinct Markers for Development of IDDM: Studies With Identical Twins

1992 • 91 citations

Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells

1991 • 90 citations

Coxsackievirus B3-induced production of tumor necrosis factor-alpha, IL-1 beta, and IL-6 in human monocytes.

1992 • 86 citations

Cytokines as Immune Effector Molecules in Autoimmune Endocrine Diseases with Special Reference to Insulin-Dependent Diabetes Mellitus

1989 • 83 citations

Cytokines in sera from insulin-dependent diabetic patients at diagnosis

1991 • 78 citations

Serum Levels of Tumor Necrosis Factor and IL-1α and IL-1β in Diabetic Patients

1991 • 77 citations

A simple, rapid and large capacity ELISA for biologically active native and recombinant human IFN gamma.

1987 • 68 citations

Preparation and Characterization of Monoclonal Antibodies Directed Against Antigenic Determinants of Recombinant Human Tumour Necrosis Factor (rTNF)

1987 • 63 citations

Proteinuria and Activated T-Lymphocytes in Diabetic Nephropathy

1988 • 54 citations

Cytotoxic effect of IFN-γ plus TNF-α on human islet cells

1991 • 48 citations

Short Exposure of Rat Pancreatic Islets to Interleukin-1β Induces a Sustained but Reversible Impairment in β-Cell Function: Influence of Protease Activation, Gene Transcription, and Protein Synthesis*

1991 • 43 citations

New cytokines and receptors make their debut in San Antonio

1991 • 24 citations

Cell‐mediated Immunity and Symptomatic Diabetic Autonomic Neuropathy

1988 • 22 citations

Cytokine plasma levels and lymphocyte subsets in patients with newly diagnosed insulin-dependent (type 1) diabetes mellitus before and following initial insulin treatment

1993 • 21 citations

Aetiology of insulin-dependent diabetes

1989 • 19 citations

Evidence of Circulating Interferon‐γ in Newly Diagnosed Diabetic Children

1984 • 19 citations

An outbreak of Group C streptococcal infection in a Maternity Unit

1994 • 14 citations

Relationship between the tumour-associated antigen 90K and cytokines in the circulation of persons infected with human immunodeficiency virus

1994 • 9 citations