Responses of Normal Cells to Ionizing Radiation

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Apoptosis

2002 • 2,190 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Cellular stress response and apoptosis in cancer therapy

2001 • 793 citations

Transforming Growth Factor‐β

1990 • 696 citations

The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway

2004 • 626 citations

TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?

2000 • 626 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

The murine transforming growth factor-beta precursor.

1986 • 492 citations

SMADs: mediators and regulators of TGF-β signaling

1998 • 476 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

1997 • 406 citations

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

1994 • 377 citations

Cellular basis of radiation-induced fibrosis

1995 • 371 citations

Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency.

2000 • 344 citations

Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?

2002 • 337 citations

Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo.

1994 • 333 citations

Death by a thousand cuts: an ever increasing list of caspase substrates

1998 • 286 citations

Radiotherapy-Related Lung Fibrosis Enhanced by Tamoxifen

1996 • 276 citations

Ceramide-mediated clustering is required for CD95-DISC formation

2003 • 270 citations

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

1994 • 255 citations

Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.

2003 • 235 citations

Stress-induced apoptosis and the sphingomyelin pathway

1997 • 234 citations

Special Report The Complexity of Endothelial Cells: A Review

1989 • 233 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: Interrelationship between the alveolar macrophage and the septal fibroblast

1992 • 216 citations

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1998 • 209 citations

Blockage of Epidermal Growth Factor Receptor-Phosphatidylinositol 3-Kinase-AKT Signaling Increases Radiosensitivity of K-RAS Mutated Human Tumor Cells In vitro by Affecting DNA Repair

2006 • 207 citations

The molecular and cellular biology of wound repair

1997 • 206 citations

Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells.

1989 • 197 citations

How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues

1998 • 191 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

Radiation effects in the lung.

1986 • 174 citations

Biochemical and biological aspects of the plasminogen activation system

1990 • 165 citations

Effects of Radiation on Cerebral Vasculature: A Review

2000 • 156 citations

Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis

1997 • 146 citations

Molecular and cellular basis of radiation fibrosis

1998 • 144 citations

Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro

1989 • 141 citations

Role of Acidic Sphingomyelinase in Fas/CD95-mediated Cell Death

2000 • 141 citations

Antitransforming growth factor–β antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation

2006 • 124 citations

Ataxia Telangiectasia-mutated Gene Product Inhibits DNA Damage-induced Apoptosis via Ceramide Synthase

1999 • 120 citations

Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis

1999 • 116 citations

Radiosensitivity of Vascular Tissue: I. Differential Radiosensitivity of Capillaries: A Quantitative in Vivo Study

1984 • 115 citations

Capillary endothelium. Target site of renal radiation injury.

1993 • 111 citations

Fibrogenic signals in patients with radiation enteritis are associated with increased connective tissue growth factor expression

2003 • 104 citations

Anti-apoptotic Bcl-2 proteins: structure, function and relevance for radiation biology

2002 • 103 citations

Terminal differentiation of human fibroblasts is induced by radiation.

1991 • 97 citations

Processing of Immunosuppressive Pro-TGF-β1,2 by Human Glioblastoma Cells Involves Cytoplasmic and Secreted Furin-Like Proteases

2001 • 96 citations

TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype

2000 • 95 citations

Potential clinical impact of normal-tissue intrinsic radiosensitivity testing

1997 • 88 citations

Interleukin 1β (IL1B) Signaling is a Critical Component of Radiation-Induced Skin Fibrosis

2006 • 87 citations

Using Plasma Transforming Growth Factor Beta-1 During Radiotherapy to Select Patients for Dose Escalation

2001 • 80 citations

The underlying cellular mechanism of fibrosis.

1996 • 74 citations

Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation.

2001 • 73 citations

Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives

2005 • 72 citations

c-Jun Is a Downstream Target for Ceramide-activated Protein Phosphatase in A431 Cells

1996 • 70 citations

Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha.

1997 • 69 citations

Differentiation state of skin fibroblast cultures versus risk of subcutaneous fibrosis after radiotherapy

1998 • 63 citations

A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients

1999 • 62 citations

Boron Neutron Capture Irradiation of the Rat Spinal Cord: Histopathological Evidence of a Vascular-Mediated Pathogenesis

1996 • 62 citations

Changes of fibrosis-related parameters after high- and low-LET irradiation of fibroblasts

2001 • 60 citations

Radiation-induced differentiation of human skin fibroblasts: relationship with cell survival and collagen production

1996 • 60 citations

Expression and activation of MMP -2, -3, -9, -14 are induced in rat colon after abdominal X-irradiation

2005 • 55 citations

Disrupting Polyamine Homeostasis as a Therapeutic Strategy for Neuroblastoma

2009 • 54 citations

On the TRAIL from p53 to apoptosis?

1997 • 52 citations

Effects of Radiation on Cerebral Vasculature: A Review

2000 • 50 citations

Radioprotection of Lungs by Amifostine is Associated with Reduction in Profibrogenic Cytokine Activity

2002 • 47 citations

Protein Kinase B/Akt-Dependent Phosphorylation of Glycogen Synthase Kinase-3β in Irradiated Vascular Endothelium

2006 • 46 citations

Fibroblast Differentiation in Subcutaneous Fibrosis after Postmastectomy Radiotherapy

2000 • 45 citations

Differential regulation of p27 and cyclin D1 by TGF-β and EGF in C3H 10T1/2 mouse fibroblasts

1996 • 42 citations

Radiation and Transforming Growth Factor-β Cooperate in Transcriptional Activation of the Profibrotic Plasminogen Activator Inhibitor-1 Gene

2005 • 41 citations

Endothelial cell subpopulations in vitro: cell volume, cell cycle, and radiosensitivity

1989 • 37 citations

Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses?

2001 • 36 citations

Dose-Response Effects of Radiation on the Permeability of Endothelial Cells in Culture

1996 • 36 citations

Transforming growth factor β1 and ethanol affect transcription and translation of genes and proteins for cell adhesion molecules in B104 neuroblastoma cells

2006 • 34 citations

Reversible alterations in cultured pulmonary artery endothelial cell monolayer morphology and albumin permeability induced by ionizing radiation

1986 • 32 citations

Effects of gamma irradiation on cultured rat and mouse microvessel endothelial cells: metastatic tumor cell adhesion, subendothelial matrix degradation, and secretion of tumor cell growth factors

1991 • 24 citations

Increased Binding and Chemotactic Capacities of PDGF-BB on Fibroblasts in Radiation Pneumonitis

2003 • 22 citations

Radioprotection of lungs by amifostine is associated with reduction in pro-fibrogenic cytokine activity

2001 • 18 citations

DIFFERENTIAL-EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA-1 ON PROTEIN-LEVELS OF P21 WAF AND CDK-2 AND ON CDK-2 KINASE-ACTIVITY IN HUMAN RD AND CCL64 MINK LUNG-CELLS

1995 • 7 citations