Molecular and cellular basis of radiation fibrosis

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Pulmonary Effects of Radiation Therapy

1977 • 575 citations

Fibrogenic cytokines and connective tissue production

1994 • 425 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

p21--Negative Regulator of the Cell Cycle

1996 • 396 citations

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

1996 • 393 citations

Cellular basis of radiation-induced fibrosis

1995 • 371 citations

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

1996 • 236 citations

Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: Interrelationship between the alveolar macrophage and the septal fibroblast

1992 • 216 citations

Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis

1994 • 207 citations

Characterization of Human Renal Fibroblasts in Health and Disease: II. In Vitro Growth, Differentiation, and Collagen Synthesis of Fibroblasts From Kidneys With Interstitial Fibrosis

1991 • 187 citations

Cytokines and pulmonary fibrosis.

1993 • 172 citations

Temporal modulation of TGF-beta 1 and beta-actin gene expression in pig skin and muscular fibrosis after ionizing radiation.

1993 • 165 citations

Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis

1997 • 146 citations

Expression of fibrogenic cytokines in rat small intestine after fractionated irradiation

1994 • 138 citations

Transforming growth factor beta: a promotor of late connective tissue injury following radiotherapy?

1990 • 131 citations

Evidence for a Positive Correlation betweenin VitroRadiosensitivity of Normal Human Skin Fibroblasts and the Occurrence of Subcutaneous Fibrosis after Radiotherapy

1994 • 125 citations

Radiation-induced G1 arrest is selectively mediated by the p53-WAF1/Cip1 pathway in human thyroid cells.

1995 • 124 citations

p21 (WAF1/CIP1) Expression Is Induced in Newly Nondividing Cells in Diverse Epithelia and during Differentiation of the Caco-2 Intestinal Cell Line

1996 • 119 citations

Terminal differentiation of human fibroblasts is induced by radiation.

1991 • 97 citations

Differentiation of fibroblast stem cells

1988 • 95 citations

Fibroblast-Matrix Interactions and Their Role in the Pathogenesis of Fibrosis

1990 • 89 citations

Long-Term Overproduction of Collagen in Radiation-Induced Fibrosis

1991 • 86 citations

DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.

1997 • 85 citations

Expression of Transforming Growth Factor-β1 in Mouse Skin During the Acute Phase of Radiation Damage

1995 • 80 citations

The Cellular Aging of Rat Fibroblasts <i>in vitro </i>Is a Differentiation Process

1979 • 77 citations

The underlying cellular mechanism of fibrosis.

1996 • 74 citations

Donor-age-related changes in the morphology, growth potential, and collagen biosynthesis in rat fibroblast subpopulations in vitro

1986 • 69 citations

Radiation-induced lung injury in vivo: Expression of transforming growth factor?Beta precedes fibrosis

1996 • 66 citations

Expression of 72-kDa Gelatinase (MMP-2), Collagenase (MMP-1), and Tissue Metalloproteinase Inhibitor (TIMP) in Primary Pig Skin Fibroblast Cultures Derived from Radiation-Induced Skin Fibrosis

1994 • 60 citations

Transforming growth factor-beta stimulates the expression of alpha 2-macroglobulin by cultured bovine adrenocortical cells.

1990 • 46 citations

Transforming Growth Factor-β1 Inhibits Human Keratinocyte Proliferation by Upregulation of a Receptor-Type Tyrosine Phosphatase R-PTP-κ Gene Expression

1996 • 35 citations

Transforming Growth Factor Beta Stimulates Mitogenically Mouse NIH3T3 Fibroblasts and Those Cells Transformed by the EJ-H-ras Oncogene

1992 • 18 citations

Procollagen-III in serum, plasminogen activation and fibronectin in bronchoalveolar lavage fluid during and following irradiation of human lung

1991 • 18 citations

Radio-induced modulation of transforming growth factor β1 sensitivity in ap53 wild-type human colorectal-cancer cell line

1996 • 13 citations

Radiation-Induced Fibrosis: Experimental Studies

1995 • 10 citations

Differentiation patterns of secondary skin fibroblasts from radiotherapy patients with different degrees of radiation-induced skin fibrosis

1997 • 1 citations