Blockage of Epidermal Growth Factor Receptor-Phosphatidylinositol 3-Kinase-AKT Signaling Increases Radiosensitivity of K-RAS Mutated Human Tumor Cells In vitro by Affecting DNA Repair

The in vitro micronucleus technique

2000 • 2,456 citations

DNA double-strand breaks: signaling, repair and the cancer connection

2001 • 2,372 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

2003 • 1,594 citations

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

2004 • 979 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

Mechanism and regulation of human non-homologous DNA end-joining

2003 • 957 citations

Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis.

2000 • 549 citations

Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase

2005 • 517 citations

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

2004 • 485 citations

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

2002 • 462 citations

Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways¹

2003 • 460 citations

Mechanisms of DNA double strand break repair and chromosome aberration formation

2004 • 392 citations

Mechanisms of Enhanced Radiation Response following Epidermal Growth Factor Receptor Signaling Inhibition by Erlotinib (Tarceva)

2005 • 374 citations

The epidermal growth factor receptor mediates radioresistance

2003 • 296 citations

Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity

2005 • 281 citations

Epidermal Growth Factor Receptor Expression in Pretreatment Biopsies From Head and Neck Squamous Cell Carcinoma As a Predictive Factor for a Benefit From Accelerated Radiation Therapy in a Randomized Controlled Trial

2005 • 245 citations

Physical Interaction between Epidermal Growth Factor Receptor and DNA-dependent Protein Kinase in Mammalian Cells

1998 • 229 citations

The erbB Family: Targets for Therapeutic Development Against Cancer and Therapeutic Strategies Using Monoclonal Antibodies and Tyrosine Kinase Inhibitors

2004 • 208 citations

Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA‐PK in human cells exposed to ionizing radiation and treated with kinase inhibitors

2004 • 197 citations

Epidermal growth factor receptor

2003 • 182 citations

Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results

2004 • 178 citations

Selective Inhibition of Ras, Phosphoinositide 3 Kinase, and Akt Isoforms Increases the Radiosensitivity of Human Carcinoma Cell Lines

2005 • 177 citations

Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.

2003 • 156 citations

Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway

2005 • 146 citations

Targeting the epidermal growth factor receptor in non-small cell lung cancer.

2003 • 136 citations

Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.

2002 • 121 citations

EGFR blockade with ZD1839 (“Iressa”) potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma

2003 • 119 citations

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA

2005 • 112 citations

The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck

2004 • 104 citations

Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer

2003 • 90 citations

Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

2005 • 88 citations

Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS

2004 • 86 citations

Modulation of DNA Repair In vitro after Treatment with Chemotherapeutic Agents by the Epidermal Growth Factor Receptor Inhibitor Gefitinib (ZD1839)

2004 • 79 citations

Molecular mechanisms underlying the interaction between ZD1839 (‘Iressa’) and cisplatin/5-fluorouracil

2003 • 77 citations

Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells

2004 • 74 citations

Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC

2004 • 68 citations

Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse

2003 • 62 citations

Proliferation and micromilieu during fractionated irradiation of human FaDu squamous cell carcinoma in nude mice

2003 • 60 citations

Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity

2005 • 53 citations

Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma

2004 • 42 citations

A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells

2000 • 41 citations

A small molecule compound inhibits AKT pathway in ovarian cancer cell lines

2005 • 40 citations

Additive interaction of gefitinib (‘Iressa’, ZD1839) and ionising radiation in human tumour cells in vitro

2004 • 30 citations

siRNA-silencing of DNA repair factors results in enhanced radiation and chemotherapy-mediated killing of human cancer cells

2003 • 21 citations

Histone H2AX sensitizes glioma cells to genotoxic stimuli by recruiting DNA double-strand break repair proteins

2003 • 8 citations