Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

2002 • 866 citations

The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway

2004 • 626 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

1996 • 526 citations

CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling

2001 • 419 citations

Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?

2002 • 337 citations

Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes

2003 • 215 citations

CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC

2002 • 206 citations

Mechanotransduction of Rat Aortic Vascular Smooth Muscle Cells Requires RhoA and Intact Actin Filaments

1999 • 203 citations

LIM-kinase 2 and Cofilin Phosphorylation Mediate Actin Cytoskeleton Reorganization Induced by Transforming Growth Factor-β

2005 • 176 citations

Prostacyclin derivatives prevent the fibrotic response to TGFβ2 by inhibiting the Ras/MEK/ERK pathway

2002 • 145 citations

Bowel injury: current and evolving management strategies

2003 • 132 citations

Rho‐dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)

2001 • 126 citations

Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy

2004 • 120 citations

Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression

2005 • 113 citations

Role of p38 MAPK in Transforming Growth Factor β Stimulation of Collagen Production by Scleroderma and Healthy Dermal Fibroblasts

2002 • 111 citations

Induction of Connective Tissue Growth Factor by Activation of Heptahelical Receptors

2000 • 108 citations

Fibrogenic signals in patients with radiation enteritis are associated with increased connective tissue growth factor expression

2003 • 104 citations

Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitors

2003 • 97 citations

Regulation of TGF-β1-induced connective tissue growth factor expression in airway smooth muscle cells

2004 • 95 citations

Effect of Administration of Lovastatin on the Development of Late Pulmonary Effects after Whole-Lung Irradiation in a Murine Model

2004 • 95 citations

Connective tissue growth factor expression and induction by transforming growth factor-β is abrogated by simvastatin via a Rho signaling mechanism

2004 • 89 citations

Gene Expression Profile in Human Late Radiation Enteritis Obtained by High-Density cDNA Array Hybridization

2004 • 70 citations

Signaling Events Required for Transforming Growth Factor-β Stimulation of Connective Tissue Growth Factor Expression by Cultured Human Lung Fibroblasts

2001 • 67 citations

Pathogenesis of intestinal strictures in Crohn's disease—an update

1995 • 65 citations

Identification of distinct molecular phenotypes in cultured gastrointestinal smooth muscle cells

1998 • 42 citations